Yishai Levy, Haya Zaltzberg, Ami Ben-Amotz, Yoram Kanter, Michael Aviram
AbstractOxidative injury by reactive oxygen species (ROS) has been suggested to explain excess prevalence of vascular complications in diabetes mellitus. ROS are normally trapped by antioxidants such as b-carotene, vitamins C and E and glutathione. The consumption of reducing equivalents in the form of NADPH may interfere with the regeneration of glutathione and ascorbic acid in diabetes mellitus. We have compared 20 patients with non-insulin-dependent diabetes mellitus (NIDDM) with no vascular complications …
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