Caries is Associated with Asthma and Epilepsy

Anjomshoaa, Ida; Cooper, Margaret E.; Vieira, Alexandre R.

doi:10.1055/s-0039-1697448

Cited by 41 publications

(30 citation statements)

References 26 publications

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“…Meta-analysis suggests that being affected by asthma doubles the risk of caries in both primary and permanent dentition (Alavaikko et al, 2011). Our data confirms the results of the meta-analysis by Alavaikko et al (2011) that suggested an association between higher caries experience and asthma in adults (Anjomshoaa et al, 2009). Individuals with asthma appear to accumulate higher amounts of dental biofilm, as well as higher salivary levels of mutans streptococci (Botelho et al, 2011).…”

Section: Introductionsupporting

confidence: 92%

“…We have been investigating the possible contribution of genetic variation of enamel formation genes in caries (Deeley et al, 2008; Patir et al, 2008; Shimizu et al, 2012), a disease that leads to demineralization of the enamel. Our data also suggest that asthmatic individuals have more severe caries experience (Anjonshoaa et al, 2009), although recent evaluations of asthmatic children show that recently implemented asthma management and educational programs are reducing caries experience in these children (Lindemeyer et al, 2012). Children with asthma more often have enamel hypoplasia and these clinical defects are consequence of either primary ameloblast defects or defective interactions between odontoblasts and ameloblasts (Musale et al, 2010).…”

Section: Discussionmentioning

confidence: 48%

“…Non-allergic asthma has a more likely onset during adulthood, female predominance, and a higher degree of severity (Bell, 2004). This is interesting since our previous studies showed more women affected by asthma (Anjomshoaa et al, 2009). …”

Section: Introductionmentioning

confidence: 65%

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Genetic variation in Ameloblastin is associated with caries in asthmatic children

Ergöz

Seymen

Gençay

et al. 2013

Eur Arch Paediatr Dent

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Aim Evidence suggests caries experience is higher in children with asthma. In this study, we compared caries experience in asthmatic and non-asthmatic children and defined whether variation in the distribution of caries experience differs between the two groups and is dependent of the presence of genetic variation in enamel formation genes. Methods Children with asthma were recruited at the Istanbul University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Pulmonary Diseases, and non-affected children were recruited at the Istanbul University, Faculty of Dentistry, Department of Pedodontics. Cases (N=100) were defined as children between the ages of 6 and 12 years with asthma and controls (N=100) as children without asthma. Cases and controls were matched by sex and age. All study subjects received a complete dental exam, provided demographic and other caries and asthma risk factors data, and a saliva sample for DNA extraction. Caries experience was defined based on DMFT/dmft and DMFS/dmfs scores. Genotypes of 11 SNPs were selected in intronic regions of enamel development genes. PCR with TaqMan chemistry were used for genotyping all selected markers. Association between caries experience (caries free versus caries affected) depending on asthma status and SNPs was tested with PLINK by logistic regression, adjusting by risk, and other preventive measures. P-values below 0.0045 (0.05/11) were considered statistically significant. Results Logistic regression analysis showed an association between AMBN rs4694075 and caries experience (p=2.525e-007). Conclusions Our study provides, for the first time, evidence that ameloblastin is associated with caries in asthmatic children.

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Section: Introductionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 48%

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Genetic variation in Ameloblastin is associated with caries in asthmatic children

Ergöz

Seymen

Gençay

et al. 2013

Eur Arch Paediatr Dent

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“…Both studies suggested the existence of an association between higher caries experience and asthma in adults [8, 9]. …”

Section: Discussionmentioning

confidence: 99%

Association between untreated carious lesions and asthma in adults at Rabat University Hospital, Morocco: a cross sectional study

et al. 2017

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BackgroundDepending on risk factors, cumulative risk of developing more dental caries by age has been reported. However, the association between dental caries and asthma is less studied among adults. The aims of this study were to evaluate the severity of untreated carious lesions in a population of asthmatic adults and to evaluate the mediation of socio-economic and oral health behaviour variables.MethodsThe study involved participants with diagnosed asthma (N = 100) and control (N = 100) subjects attending a tertiary hospital. Groups were matched by age and gender. Asthma was the exposure of interest. The outcome measure was the rate of carious lesions. Recorded variables included demographics, socio-economic status, tooth brushing habits and oral health status using WHO criteria. Poisson regression analysis examined the association between asthma and untreated dental caries.ResultsThe adjusted model, after the inclusion of individuals’ behaviours regarding oral health, social determinants and asthma, revealed a significant association between the number of untreated carious lesions and asthma (PR = 1.23; 95% CI 1.23–1.58; p < 0.001).ConclusionPatients with asthma showed a greater number of untreated carious lesions. Looking forward, better understanding of the association between asthma and oral health may require exploiting the interactions of behavioural, social determinant and biological factors.

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“…[5360] Promotion of oral health has, therefore, been suggested as a way to promote systemic health, since there is a possible role of oral infections as a risk factor for systemic disease. [61] It is imperative for medical and dental practitioners to take note of these recent findings. The best time to pass this knowledge across in our view is during the training of these professionals.…”

Section: Chronic Periodontitismentioning

confidence: 99%

Periodontitis and systemic diseases: A literature review

Arigbede¹,

Babatope²,

Bamidele³

2012

J Indian Soc Periodontol

119

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Studies have revealed possible link between periodontitis and different systemic diseases. There is need to review this interesting subject. The aims are: to provide a comprehensive literature that can easily be consulted, on the subject; to draw the attention of health practitioners to the impact of oral health on the general well-being; and to emphasize the need for a deeper interaction between medical and dental training. The Medline database was searched for relevant literature by combining each of the following terms, “oral health,” “oral infection,” “periodontitis,” with “systemic diseases.” Manual library search and review of bibliographies of published literature were also conducted. Periodontitis is a constant potential source of infection and has been considered as a separate risk factor for some cardiovascular, respiratory, endocrine, musculoskeletal, and reproductive system related abnormalities. Oral health impacts on the general well-being, and if comprehensive health care is ever to be achieved, oral health should not be seen as a separate, distant, and less important area of health, which is totally unrelated to lifespan and its quality.

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Caries is Associated with Asthma and Epilepsy

Cited by 41 publications

References 26 publications

Genetic variation in Ameloblastin is associated with caries in asthmatic children

Genetic variation in Ameloblastin is associated with caries in asthmatic children

Association between untreated carious lesions and asthma in adults at Rabat University Hospital, Morocco: a cross sectional study

Periodontitis and systemic diseases: A literature review

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