Cardiovascular risk factors, lifestyle, and social determinants: a cross-sectional population study

Palomo, Luis; Félix-Redondo, Francisco-Javier; Lozano-Mera, L.; Pérez-Castán, José-Fernando; Fernández-Bergés, Daniel; Buitrago, Francisco

doi:10.3399/bjgp14x681793

Cited by 21 publications

(22 citation statements)

References 41 publications

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“…Many studies proved that HTN and hypercholesterolemia act synergistically with cardiovascular risk factors. 9,41 However, dietary treatment of these disorders can make a substantial contribution to reducing hyperlipidemia, improving glycemic control, and treating HTN. Unfortunately, energy intake as well as energy percentage from protein and fat were higher than the recommended quantity in both groups (proper intake of energy should equal 1800 kcal/d, with energy from proteins <15% of energy intake and that from fats <30% of energy consumption).…”

Section: Discussionmentioning

confidence: 99%

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Grygiel-Górniak

Kaczmarek

Mosor

et al. 2015

J of Clinical Hypertension

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The aim of this study was to test the association of peroxisome proliferator-activated receptor (PPAR-c2) (Pro12Ala, C1431T) and b3-AR (Trp64Arg) polymorphisms with metabolic, nutritional, and blood pressure parameters in 271 postmenopausal women (151 hypertensive and 120 normotensive controls). The TaqMan genotyping assay and restriction fragment length polymorphism methods were used to determine the distributions of selected alleles and genotype frequencies. Nutritional status was determined by a bioimpedance method and dietary habits were assessed via 7-day dietary recall. The distribution of selected genotypes and allele frequencies did not differ between hypertensive women and normal controls after analysis by chi-square test. The postmenopausal hypertensive women were older and had higher body fat mass, serum glucose, and triglyceride levels. The cluster analysis showed that the hypertensive group with Pro12Pro genotype had highest pulse pressure and mean arterial pressure values when compared with Pro12Ala patients. In the logistic regression analysis, blood glucose (Pro12Ala polymorphism) and energy intake (C1431Tand T1431T polymorphisms) determined hypertension. J Clin Hypertens (Greenwich). 2015;17:549-556. ª 2015 Wiley Periodicals, Inc.Increased body weight, insulin resistance (IR), hyperglycemia, abnormal blood lipid profiles, oxidative stress, and hypertension (HTN) contribute to cardiovascular diseases.1-4 With aging, a greater incidence of HTN and cardiovascular complications is widely observed in postmenopausal women compared with premenopausal women. 5,6 The hypertensive state is often associated with dyslipidemia, 7 obesity (nearly 40% of hypertensive patients are obese), 8 and IR. 9 Moreover, blood pressure (BP) in women presents specific hemodynamic characteristics, and, in the postmenopausal age, the role of pulse pressure (PP) predominates over that of mean arterial pressure (MAP) in the mechanism of high BP. The stiffness of the large elastic arteries in cardiothoracic (central) circulation increases with age 10 and it results in progressive age-associated elevations in SBP and PP. These changes accelerate after the age of 50 and are much greater in women than in men. 5,6 Studies have shown that PPAR-c2 polymorphisms (Pro12Ala, C14131T) and b-adrenergic receptor gene polymorphisms (b3-AR Trp64Arg) may have an important impact on adipose tissue, 11 metabolic parameters, 12,13 and inflammation in the vasculature, and through their influence determine high BP.14,15 Some data have indicated that Pro12Pro normoglycemic homozygotes had significantly higher incidence of HTN 16 and higher diastolic BP (DBP) 17 when compared with Ala12 carriers. However, the association between the Pro12Ala variants and arterial BP remains controversial and most other studies could not demonstrate such an association, 18,19 while some even indicated that Ala12 carriers had higher BP. 20 Besides this, the polymorphisms have been mostly studied separately (not in constellation) in patients with diabetes mellitus or o...

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Section: Discussionmentioning

confidence: 99%

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Grygiel-Górniak

Kaczmarek

Mosor

et al. 2015

J of Clinical Hypertension

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“…Auch haben soziale und gesellschaftliche Faktoren wie z. B. Arbeitslosigkeit oder auch Lebens-und Wohnverhältnis-se einen weitgehenden Einfluss auf die gesundheitliche Lage und das Gesundheitsverhalten der Bevölkerung [30][31][32][33] und sollten zukünftig miteinbezogen werden. Zudem ist es wünschenswert, psychische Belastungen und Störungen, die ebenfalls als wesentliche Risikofaktoren für Herz-Kreislauf-Erkrankungen gelten, in weiteren Untersuchungen nä-her zu betrachten [34,35] …”

Section: Fazitunclassified

Regionale Unterschiede in der Prävalenz von kardiovaskulären Risikofaktoren bei Männern und Frauen in Deutschland

Diederichs

Neuhauser

Kroll

et al. 2016

Bundesgesundheitsbl

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“…The associations between sociodemographic factors, diet and lifestyle factors for hypercholesterolemia have been documented in many epidemiological and observational studies [7,8]. Dietary habits and lifestyle among Chinese people have changed a great deal during the last 10 years, especially among middle-aged people.…”

Section: Introductionmentioning

confidence: 99%

Trends in Determinants of Hypercholesterolemia among Chinese Adults between 2002 and 2012: Results from the National Nutrition Survey

Song

Man

et al. 2017

Nutrients

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Hypercholesterolemia is a known risk factor for cardiovascular diseases and affects a high proportion of the population. This study aimed to assess and compare the determinants of hypercholesterolemia among Chinese adults aged 18 years and above, from 2002 to 2012. The study used a stratified multistage cluster sampling method to select participants. Sociodemographic and lifestyle information was collected during face-to-face interviews. Dietary intake was calculated by 3-day, 24-h dietary records in combination with weighted edible oil and condiments. Hypercholesterolemia was defined as total cholesterol above 6.22 mmol/L (240 mg/dL) from fasting blood samples. The study included 47,701 (mean age 43.0 years) and 39,870 (mean age 51.0 years) participants in 2002 and 2010–2012 surveys respectively. The weighted prevalence of hypercholesterolemia increased from 1.6% (2.1% urban, 1.0% rural) in 2002 to 6.0% (6.4% urban, 5.1% rural) in 2012. The intake of plant-based food decreased but the intake of pork increased over the 10 years. A high intake of protein and pork, alcohol drinking and overweight/obesity were positively associated with hypercholesterolemia. Neither education nor fruit and vegetable intake were associated with hypercholesterolemia. In conclusion, the burden of hypercholesterolemia increased substantially between 2002 and 2012 in China. Unhealthy lifestyle factors and change in traditional dietary pattern were positively associated with hypercholesterolemia. Further research on the role of diet in the development and prevention of hypercholesterolemia is needed.

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Cardiovascular risk factors, lifestyle, and social determinants: a cross-sectional population study

Cited by 21 publications

References 41 publications

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Regionale Unterschiede in der Prävalenz von kardiovaskulären Risikofaktoren bei Männern und Frauen in Deutschland

Trends in Determinants of Hypercholesterolemia among Chinese Adults between 2002 and 2012: Results from the National Nutrition Survey

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