Cardiovascular malformations in the fetal alcohol syndrome

Steeg, Carl N.; Woolf, Paul K.

doi:10.1016/0002-8703(79)90290-4

Cited by 40 publications

(15 citation statements)

References 12 publications

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“…Cardiac malformations exist in children with fetal alcohol syndrome (44,53) and animal models of prenatal alcohol exposure (43,57), and cardiac hypertrophy has been found in children with fetal alcohol syndrome (68). Prenatal ethanol exposure has been shown to cause ultrastructural abnormalities in cardiac muscle cells in mice (63) and a significant difference in left ventricular muscle width in male rats (41).…”

Section: Discussionmentioning

confidence: 99%

Sexually dimorphic effects of maternal alcohol intake and adrenalectomy on left ventricular hypertrophy in rat offspring

Wilcoxon

Schwartz

Aird³

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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In humans, low birth weight and increased placental weight can be associated with cardiovascular disease in adulthood. Low birth weight and increased placental size are known to occur after fetal alcohol exposure or prenatal glucocorticoid administration. Thus the effects of removing the alcohol-induced increase in maternal corticosterone by maternal adrenalectomy on predictors of cardiovascular disease in adulthood were examined in rats. Alcohol exposure of dams during the last 2 wk of gestation resulted in significantly decreased fetal weight and increased placental weight on gestational day 21. Adult female, but not male, offspring of alcohol-consuming mothers exhibited left ventricular hypertrophy. Placental 11β-hydroxysteroid dehydrogenase-2 (11β-HSD-2) mRNA levels, measured by Northern blot, were decreased in females but not males. Adrenalectomy of alcohol-consuming dams reversed the increase in placental weight and the decrease in female placental 11β-HSD-2 expression and eliminated the left ventricular hypertrophy of adult female offspring. These data suggest that alcohol-induced changes in placental 11β-HSD-2 mRNA levels and left ventricular weight are coupled in female offspring only and depend on maternal adrenal status.

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Section: Discussionmentioning

confidence: 99%

Sexually dimorphic effects of maternal alcohol intake and adrenalectomy on left ventricular hypertrophy in rat offspring

Wilcoxon

Schwartz

Aird³

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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“…Cardiovascular anomalies may include septal defects and hypoplastic pulmonary arteries (Dupuis et al, 1978;Steeg and Woolf, 1979), while renal complications include pyelonephritis, painless hematuria, hydronephrosis and uni-or bilateral hypoplasia (Qazi et al, 1980;Steinhausen et al, 1982). In addition to associated renal and cardiovascular anomalies, orthopedic abnormalities such as radioulnar synostosis, camptodactyly of the fingers, brachydactyly and clinodactyly of the toes and fifth fingers have also been reported (Speigel et al, 1979).…”

Section: Article In Pressmentioning

confidence: 99%

Fetal alcohol spectrum disorders: A practical clinical approach to diagnosis

Manning

Hoyme

2007

Neuroscience & Biobehavioral Reviews

126

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“…Though reports on FASD pathophysiology have primarily focused on the fetal/neonatal brain and the associated behavioral sequelae [1, 3], alcohol-induced effects on the maternal and fetal cardiovascular system including altered systemic hemodynamics [4], cardiovascular malformations [5, 6], vascular function deficits [7], as well as reproductive vascular abnormalities [8–10] have been described. However, few studies have utilized state of the art novel high throughput mass spectrometric proteomic technologies that have the potential to shed light on the multi-mechanistic perspectives underlying gestational alcohol-induced deficits including those on the maternal compartment.…”

Section: Introductionmentioning

confidence: 99%

Alcohol-induced alterations in maternal uterine endothelial proteome: A quantitative iTRAQ mass spectrometric approach

Ramadoss¹,

Magness²

2012

Reproductive Toxicology

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Objective To quantitate alcohol-induced alterations in the maternal uterine endothelial proteome utilizing iTRAQ-based mass spectrometry. Study Design Uterine artery endothelial cells from third trimester pregnant ewes were FAC sorted, validated and treated without or with binge-like alcohol. Lysates were trypsin digested, iTRAQ-labeled, and analyzed using nano LC MS/MS. Results Alcohol significantly upregulated 14 and downregulated 17 proteins (P<0.05) including those related to cell structure, transcription/translation regulation, histones, Ca+2/NO, and redox balance. Gene ontology and ArrayTrack analyses revealed alterations to protein processing, binding, and nutrient metabolism pathways. Further, alcohol altered proteins previously correlated with Fetal Alcohol Spectrum Disorders (FASD) and those that regulate epigenetic, transcriptional, and translational processes. Conclusions Alcohol differentially alters the proteome in the maternal uterine compartment at the level of the endothelium. iTRAQ mass spectrometry provides a robust high throughput platform to comprehend the multi-mechanistic actions of alcohol and develop appropriate biomarkers and ameliorative measures for FASD.

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Cardiovascular malformations in the fetal alcohol syndrome

Cited by 40 publications

References 12 publications

Sexually dimorphic effects of maternal alcohol intake and adrenalectomy on left ventricular hypertrophy in rat offspring

Sexually dimorphic effects of maternal alcohol intake and adrenalectomy on left ventricular hypertrophy in rat offspring

Fetal alcohol spectrum disorders: A practical clinical approach to diagnosis

Alcohol-induced alterations in maternal uterine endothelial proteome: A quantitative iTRAQ mass spectrometric approach

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