Cardiovascular Magnetic Resonance Characteristics in Children With Hypertrophic Cardiomyopathy

Yan, Chaowu; Zhao, Shihua; Ji, Ling; Li, Li; Fang, Wei

doi:10.1161/circheartfailure.113.000414

Cited by 47 publications

(60 citation statements)

References 25 publications

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“…Late Gadolinium Enhancement on Cardiac Magnetic Resonance (CMR) imaging 3 studies 38,39,40 were identified that looked at the predictive value of late gadolinium enhancement on CMR as a risk factor for SCD in childhood HCM. They reported an increased incidence of LGE in patients with adverse outcomes.…”

Section: Hour Blood Pressure Monitoring 13mentioning

confidence: 99%

Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis

Norrish

Cantarutti

Pissaridou

et al. 2017

Eur J Prev Cardiolog

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Results: Twenty five studies (3394 patients) met inclusion criteria. We identified four conventional major risk factors which were evaluated in at least 4 studies and found to be statistically associated with an increased risk of death in at least 2 studies: previous adverse cardiac event (pooled hazard ratio 5.4 (95% CI 3.67-7.95), p <0.001 ); non-sustained ventricular tachycardia (pooled hazard ratio 2.13 (95% CI 1.21-3.74), p=0.009); unexplained syncope (pooled hazard ratio 1.89 (95% CI 0.69-5.16), p=0.22);and extreme left ventricular hypertrophy (pooled hazard ratio 1.80 (95% CI 0.75-4.32), p=0.19). Left atrial diameter did not meet the major risk factor criteria, however is likely to be an additional significant risk factor. 'Minor' risk factors included a family history of sudden cardiac death, gender, age, symptoms, ECG changes, abnormal blood pressure response to exercise and left ventricular outflow tract obstruction. Conclusions:A lack of well-designed, large population based studies in childhood hypertrophic cardiomyopathy means the evidence-base for individual risk factors is not robust. We have identified four clinical parameters which are likely to be associated with increased risk of SCD, SCD-equivalent event or CVD. Multi-centre prospective studies are needed to further determine their relevance in predicting SCD in childhood HCM and to identify novel risk markers. Condensed abstract:3 A systematic review and meta-analysis of clinical risk factors predicting sudden cardiac death (SCD) in childhood hypertrophic cardiomyopathy (HCM) was performed identifying four 'major' factors: previous adverse cardiac event; non-sustained ventricular tachycardia; syncope and extreme left ventricular hypertrophy. Well-designed multi-centre studies are required in the future to confirm these findings.4

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Section: Hour Blood Pressure Monitoring 13mentioning

confidence: 99%

Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis

Norrish

Cantarutti

Pissaridou

et al. 2017

Eur J Prev Cardiolog

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“…The imaging protocol and analysis have been described previously. 18,19 Briefly, a true fast imaging with steady-state precession (TrueFisp) sequence was used to obtain cine images, which included LV 2-chamber and 4-chamber long-axis view, LVOT view, and LV short-axis views (contiguous slices from atrioventricular ring to apex).…”

Section: Methodsmentioning

confidence: 99%

Significance and Determinants of Cardiac Troponin I in Patients With Obstructive Hypertrophic Cardiomyopathy

Zhang

Liu

Yuan

et al. 2015

The American Journal of Cardiology

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“…The most important application is the detection and grading of the severity of myocardial fibrosis, which appears to be an important risk factor for subsequent ventricular arrhythmias and sudden cardiac death in both adults and children (1,2,16).…”

Section: Workup and Diagnosismentioning

confidence: 99%

Hypertrophic cardiomyopathy in children

Arghami

Dearani

Said

et al. 2017

Ann. Cardiothorac. Surg.

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Hypertrophic cardiomyopathy (HCM) occurs in 1 of 500 adults and is considered to be one of the most common causes of death in young people under 35 years of age. Children with HCM are usually asymptomatic and the overall annual mortality beyond the first year of life is 1%. Septal myectomy is safe and effective in children with obstructive HCM and published data shows improved late survival compared to untreated HCM. Patient selection and surgical expertise remain critical components to ensuring successful outcomes of septal myectomy, particularly when considering prophylactic myectomy in a seemingly asymptomatic patient.

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Cardiovascular Magnetic Resonance Characteristics in Children With Hypertrophic Cardiomyopathy

Abstract: Background-Cardiovascular magnetic resonance has provided important information on the diagnosis and risk stratification of hypertrophic cardiomyopathy (HCM) in adults; however, comparable data are absent for HCM in children.

Cited by 47 publications

References 25 publications

Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis

Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis

Significance and Determinants of Cardiac Troponin I in Patients With Obstructive Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy in children

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