Cardiovascular Events in Pregnancy With Hypertrophic Cardiomyopathy

Pregnancy in women with hypertrophic cardiomyopathy: data from the European Society of Cardiology initiated Registry of Pregnancy and Cardiac disease (ROPAC)

“…The rates of these vary from 15% to 48% depending on the study design and patient population. 5,7,8,15,16 In our contemporary registry, almost a quarter of pregnant women with HCM developed either HF or arrhythmia and most of these complications occurred during the 3rd trimester or postpartum, consistent with the reported literature.…”

“…Avilla et al 7 reported an arrhythmia rate of only 13% among 23 pregnant women with HCM, a rate lower than found in non-pregnant women with HCM and episodes of palpitations and arrhythmia during pregnancy in women with HCM which were similar to those experienced before their pregnancy. 6,7 In contrast, in a retrospective review of 27 pregnancies in 23 women with HCM, Tanaka et al 8 reported a cardiovascular event rate of 48%; the vast majority involved an arrhythmia and occurred during the 3rd trimester. In a series of 8 high risk women with HCM who had an implantable cardioverter defibrillator (ICD), 2 patients had VT (1 sustained and 1 non-sustained), and 2 had SVT.…”

“…However, most of the reports are retrospective or include small case series and may suffer from selection bias including more severe cases. [3][4][5][6][7][8] This prospective study aims to provide information on the outcome of pregnancy in a cohort of pregnant women with HCM recruited to the observational, contemporary, worldwide Registry of Pregnancy and Cardiac disease (ROPAC). Such information may be helpful in pre-pregnancy counselling of women with HCM and identifying women at high-risk of an adverse outcome.…”

Deletion of the Serotonin Receptor Type 3A in Mice Leads to Sudden Cardiac Death During Pregnancy

“…Pregnancy is a well-known condition during which the heart undergoes various hemodynamic and structural changes, with an increase in cardiovascular events. 13, 14 It was reported that the serum serotonin level increased 2-fold during pregnancy. 15 Therefore, we evaluated the change in serotonin and Tph1 in the heart during pregnancy.…”

Cardiovascular Events in Pregnancy With Hypertrophic Cardiomyopathy

“…9 This is an important clinical study providing initial information on cardiovascular events during pregnancy in Japanese HCM patients. The authors clarified that the cardiovascular events occurred in more than half of pregnancies complicated with HCM, and the arrhythmia is the most common cardiovascular event.…”