1957
DOI: 10.3181/00379727-94-22951 View full text |Buy / Rent full text
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Abstract: Hutcheon and his colleagues ( 1 ) found that in animals. tetrahydrozoline (2-( 1.2,3.4tetrahydro-1 -naphthyl) imidazoline hydrochloride) caused an increase in arterial pressure similar to that produced by epinephrine. However. it differed qualitatively from the epinephrine effect in that onset of hypertension was slower and its duration was more prolonged. Increase in blood pressure caused by tetrahydrozoline was diminished, but was never reversed by adrenolytic agents such as phentolamine. The sympathomimetic… Show more

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“…Tolazoline (Priscoline) and phentolamine (Regitine) are followed by abrupt falls in arterial pressure, whereas tetrahydrolozine ( Tyzine ) is followed by an immediate rise in arterial pressure, then by a prolonged fall. 7 Although reduction in arterial pressure following these agents is fairly predictable, the short duration of action of tolazoline and phentolamine and the pressor properties of tetrahydrolozine precluded their use in hypertension. A new imidazoline compound which produces a fall in arterial pressure lasting 5 to 6 hours, a decrease in heart rate, and sedation has attracted some attention.…”
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“…Tolazoline (Priscoline) and phentolamine (Regitine) are followed by abrupt falls in arterial pressure, whereas tetrahydrolozine ( Tyzine ) is followed by an immediate rise in arterial pressure, then by a prolonged fall. 7 Although reduction in arterial pressure following these agents is fairly predictable, the short duration of action of tolazoline and phentolamine and the pressor properties of tetrahydrolozine precluded their use in hypertension. A new imidazoline compound which produces a fall in arterial pressure lasting 5 to 6 hours, a decrease in heart rate, and sedation has attracted some attention.…”
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