Cardiovascular Effects of Sildenafil During Exercise in Men With Known or Probable Coronary Artery Disease

Abstract

In men with stable CAD, sildenafil had no effect on symptoms, exercise duration, or presence or extent of exercise-induced ischemia, as assessed by exercise echocardiography.

Sildenafil Citrate Does Not Alter Ventricular Repolarization Properties: Novel Evidence from Dynamic QT Analysis

“…The explanation they gave for this kind of effect was that the heart rate increase induced by sildenafil resulted from a sympathetic drive augmentation to the heart rather than direct electrophysiological effects. In contrast, sildenafil did not cause an increase and even caused a decrease in the heart rate and this effect could be explained by prolonged rest position during post‐drug phase in our study in accordance with previous studies 22,23 . Also, Agelink et al 24 did not find any effect of sildenafil on sympathovagal balance (low power/high power of power spectral heart rate variability) of the heart.…”

The effect of tadalafil on the time to exercise‐induced myocardial ischaemia in subjects with coronary artery disease

“…Although not an a priori endpoint of our study, we showed that tadalafil decreased resting SBP and attenuated the exercise‐induced increase in SBP in subjects with CAD. The blood pressure lowering effects of tadalafil in subjects with CAD are similar to those reported in studies with sildenafil [22, 23] and vardenafil [19], however, the changes may be more relevant when one considers the comparatively long half‐life of tadalafil (i.e. half‐life of tadalafil = 17.5 h, half life of sildenafil and vardenafil =∼4 h) and that we used the lower licensed dose of tadalafil.…”

Sildenafil enhances central hemodynamic responses to exercise, but not V̇o2peak, in people with diabetes mellitus

“…Performing the study with a longer period of sildenafil use may have negated this uncertainty; however, the study was designed to measure the acute physiological effect of sildenafil rather than the longer term clinical effects of regular use. The delay of 1 h after sildenafil ingestion to begin exercise has been used by others (2,19) and is supported by the published pharmacological profile of sildenafil (21).…”