Cardiovascular effects of oblongine chloride, an alkaloid from Leontice leontopetalum, in the anaesthetized guinea‐pig

Abstract

The effects of (-)oblongine chloride, a quaternary alkaloid from Leontice leontopetalum on blood pressure, heart rate and blood Row of the anaesthetized guinea-pig were studied. At doses ranging from 0.5 mg/kg to 30 mg/kg, i.v., oblongine chloride caused a dose-dependent reduction of systolic and diastolic blood pressure. These doses were associated with an increase in heart rate. Propranolol (5 mg/kg) failed to block the effects of oblongine chloride on systolic and diastolic blood pressure but significantly reduced the increase in heart rate observed with low doses (0.5-6 mg/kg) of oblongine chloride. In doses ranging from 0.05 mg/kg to 0.5 mg/kg, oblongine chloride caused a small increase in blood Row. Larger doses (1.5,4.5,15 and 30 mglkg) caused an initial decrease followed by an increase of blood Row. The net effect of cumulative doses was an increase in blood Row over the control value. These observations suggest that oblongine chloride may have potential haernodynamic effects and that these effects are not mediated by Fadrenergic receptor stimulation.

Possible mechanisms of action of the hypotensive effect ofAnnona muricata(soursop) in normotensive Sprague–Dawley rats

“…Essential oils such as β-caryophyllene, δ-cadinene, epi-α-cadinol and α-cadinol have also been isolated from the A. muricata plant (Pelissler et al, 1994;Kossouoh et al, 2007). Some essential oil like beta-caryophyllene present in other plants have been reported to exhibit hypotensive and vasodilator activities (Damiani et al, 2004;Sundufu & Shoushan, 2004;Morteza-Semnani, 2006;Kamboj & Saluja, 2008) and the presence of such compounds in A. muricata might possibly contribute to the cardiovascular effects observed with the aqueous plant extract (Abdalla et al, 1995).…”

Medicinal plants with beneficial effects on heart

“…The net effect of cumulative doses was an increase in blood flow over the control value. Accordingly, oblongine chloride possessed potential haemodynamic effects, which were not mediated by β-adrenergic receptor stimulation (121)(122) .…”