Cardiovascular Effects of Halothane in Man

Eger, Edmond I.; Smith, N. Ty; Stoelting, Robert K.; D, Cullen; Kodis, Leslie B.; Whitcher, Charles E.

doi:10.1097/00000542-197005000-00004

Cited by 209 publications

(60 citation statements)

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“…They also pointed out that their NzO studies were done after the initial circulatory adaptation to halothane had occurred. 12 Maintenance of anaesthesia with halothane and nitrous oxide is common in patients having CABG. In the period after endotracheal intubation but before the autonomic stimulation of the surgical incision, a fall in blood pressure can occur.…”

Section: Di~;cussionmentioning

confidence: 99%

Nitrous oxide added to halothane reduces coronary flow and myocardial oxygen consumption in patients with coronary disease

et al. 1983

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Section: Di~;cussionmentioning

confidence: 99%

Nitrous oxide added to halothane reduces coronary flow and myocardial oxygen consumption in patients with coronary disease

et al. 1983

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“…6 Halothane remains the anaesthetic used most frequently for inhalational induction in children because it produces less airway irritation than enflurane 7 , isoflurane 8 or desflurane. Despite its efficacy and frequency of use, however halothane is not an ideal induction agent because of its potential to cause bradycardia, hypotension and ventricular ectopy 9 . The pleasant non pungent odour of sevoflurane and its low blood gas partition coefficient suggest that it may be a suitable alterative to halothane for use in paediatric anaesthesia 10 .…”

Section: Discussionmentioning

confidence: 99%

Induction characteristic of general anaesthesia in children- a comparative study between sevoflurane and halothane

Wadud

Hasanat³

et al. 2014

j Bangladesh Soc Anaesthesiologists

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Background Inhalational induction of anaesthesia remains of fundamental technique in paediatric anaesthesia. Halothane used most frequently for inhalational induction in children. Halothane is not an ideal induction agent because of its potential to cause bradycardia, hypotension and ventricular ectopy. The pleasant nonpungent order of sevoflurane, faster induction of anaesthesia and stable vital signs during induction suggest that it may be a suitable alternative to halothane for use in paediatric anaesthesia. Objectives The aim of study is to compare the induction time and haemodynamic response during induction of sevoflurane and halothane. Methods A total number of 60 patients, age within 1-12 years (ASA grade I & II) were selected randomly into two groups, thirty in each group. Group A induction was done by halothane and Group B induction was done by sevoflurane. Anaesthesia was induced with 60% N2O and 40% O2 and starting inspired concentration of halothane was 1% or sevoflurane was 2% followed by stepwise increases in the inspired concentrations of either sevoflurane (1.5-2% increments) or halothane (0.5-1% increments) every three to four breath until the patients no longer blinked in response to touching the eye lashes. Arterial pressure, heart rate, oxygen saturation (SPO2) were recorded every minute for 3 minutes during induction and induction time was recorded. Results Induction time was significantly shorter in the sevoflurane group compared to the halothane group (P < 0.001). In haemodynamic profile heart rate and mean arterial pressure were significantly reduced in halothane group while no significant changes were observed in sevoflurane group during induction period (P < 0.001). Conclusion The study concludes that induction of anaesthesia was faster with sevoflurane than halothane. Vital signs were stable with sevoflurane during induction period. DOI: http://dx.doi.org/10.3329/jbsa.v24i1.19794 Journal of Bangladesh Society of Anaesthesiologists 2011; 24(1): 13-17

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“…In consequence, adrenergic stimulation causes a twofold majority of the vascular resistance value within the precapillary region when compared with the postcapillary region. 12,41,42 The precapillary sphincter is also subject to sympathetic adrenergic stimulation, although it is local factors that are clearly predominant in terms of vascular control at the microcirculation level, especially at the capillary level. 18,21,42,43 Humoral Factors…”

Section: Neural Factormentioning

confidence: 99%

Is the knowledge on tissue microcirculation important for microsurgeon?

Kusza

Siemionow

2011

Microsurgery

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This review article outlines the importance of knowledge on the hemodynamics of microcirculatory responses during free tissue transfer procedures. Anatomy and pathophysiology of peripheral microcirculation are outlined in the context of its responses during microsurgical procedures submitted to ischemia and reperfusion injury. The factors influencing the patient's outcome such as neural, humoral, and muscular regulations and prostoglandins, kinins, nitric oxide actions, and so on are outlined. In addition, other important factors influencing microcirculatory responses are discussed. The goal of this review article is to introduce nonsurgical factors independent of the microsurgeon's control which, via changes in microcirculatory hemodynamics, may contribute to free flap survival and final patient's outcomes. Thus, we hope that this overview of the pathophysiology of tissue microcirculation will help microsurgeons to monitor factors beyond control of vessel patency and technical aspects of microvascular anastomosis.

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Cardiovascular Effects of Halothane in Man

Cited by 209 publications

References 0 publications

Nitrous oxide added to halothane reduces coronary flow and myocardial oxygen consumption in patients with coronary disease

Nitrous oxide added to halothane reduces coronary flow and myocardial oxygen consumption in patients with coronary disease

Induction characteristic of general anaesthesia in children- a comparative study between sevoflurane and halothane

Is the knowledge on tissue microcirculation important for microsurgeon?

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