Cardiovascular disease, inflammation, and mRNA stability

Herman, Allison B.; Autieri, Michael V.

doi:10.18632/aging.101619

Cited by 4 publications

(3 citation statements)

References 7 publications

(7 reference statements)

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“…In addition, RNA catabolic process is another identified GO enrichment term. Previous studies have demonstrated that RNA stability provides a rapid level of regulation that can have major effects in maintaining global inflammation ( Herman and Autieri, 2018 ; Nyati et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Liu

et al. 2021

Front. Genet.

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ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of osteonecrosis (ON) in the UK Biobank with pre-computed mRNA expression reference weights of muscle skeleton (MS) and blood. The ON-associated genes identified by TWAS were further subjected to gene ontology (GO) analysis by the DAVID tool. Finally, a trans-omics comparative analysis of TWAS and genome-wide mRNA expression profiling was conducted to identify the common genes and the GO terms shared by both DNA-level TWAS and mRNA-level expression profile for ONFH.ResultsTWAS totally identified 564 genes that were with PTWAS value <0.05 for MS and blood, such as CBX1 (PTWAS = 0.0001 for MS), SRPK2 (PTWAS = 0.0002 for blood), and MYO5A (PTWAS = 0.0005 for blood). After comparing the genes detected by TWAS with the differentially expressed genes identified by mRNA expression profiling, we detected 59 overlapped genes, such as STEAP4 [PTWAS = 0.0270, FC (fold change)mRNA = 7.03], RABEP1 (PTWAS = 0.010, FCmRNA = 2.22), and MORC3 (PTWAS = 0.0053, FCmRNA = 2.92). The GO analysis of TWAS-identified genes discovered 53 GO terms for ON. Further comparing the GO results of TWAS and mRNA expression profiling identified four overlapped GO terms, including cysteine-type endopeptidase activity (PTWAS = 0.0006, PmRNA = 0.0227), extracellular space (PTWAS = 0.0342, PmRNA = 0.0012), protein binding (PTWAS = 0.0112, PmRNA = 0.0106), and ATP binding (PTWAS = 0.0464, PmRNA = 0.0033).ConclusionSeveral ONFH-associated genes and GO terms were identified by integrating TWAS and mRNA expression profiling. It provides novel clues to reveal the pathogenesis of ONFH.

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Section: Discussionmentioning

confidence: 99%

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Liu

et al. 2021

Front. Genet.

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“…In studies carried out in human cohorts, the profile of N6-methyladenosine (m6A) decreases and this decrease negatively affects the levels of several mRNAs (Min et al 2018). Dysregulation of mRNA stability has been associated with aged tissues and importantly with the progression of age-associated diseases like atherosclerosis and inflammatory profile (Herman and Autieri 2018;Masuda et al 2009). However, the information about the dynamic of RBPs during aging and immunosenescence is not clear and needs further research (Herman and Autieri 2018).…”

Section: Deregulation Of the Stability Of Mrna Is Associated With Agi...mentioning

confidence: 99%

Regulation of Synthesis of Coenzyme Q10

Cascajo-Almenara

López-Lluch

2020

Coenzyme Q in Aging

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The regulation of gene expression needs many mechanisms of control which are multiple and diverse, encompassing from DNA structure to synthesis, modification and location of proteins. These processes, in addition to being tissuespecific, change during embryonic development and throughout the life of the organism. CoQ 10 is essential to maintain cell homeostasis and to increase life-span. CoQ 10 biosynthesis pathway is strictly regulated and this program involves different levels of regulation (transcriptional, post-transcriptional and post-translational).Here we have focused on processes of post-transcriptional regulation governed by RNA-binding proteins (RBPs) and review the role of these RBPs in senescence and aging. Finally, we report post-transcriptional and post-translational events involved in the regulation of several COQs genes involved in the CoQ 10 synthesis complex assembly. The knowledge of processes that control CoQ 10 levels in cells is key to develop therapies to stimulate the endogenous synthesis of CoQ 10 .

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“…This has resulted in worldwide quarantine, wearing of masks, social distancing, and other methods to reduce close contact with others until a viable treatment option has been determined [8,9]. Open Access Journal [25], involved with tumor [26][27][28] and cardiovascular issue treatments [29][30][31], but none involved with respiratory-related infections. mRNA focuses primarily on affecting the cell cytoplasm to produce the viral RNA proteins on the surface of the cell for the antigens to be made.…”

Section: Introductionmentioning

confidence: 99%

mRNA Vaccine Review against COVID-19 with Potential Applications to Improve Efficacy and Targeting

Ms¹,

Sa²

2021

Int J Vaccine Immunizat

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Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is the cause of the pandemic that has affected over 213 countries and there are over 21 million confirmed cases in the United States. Intense research efforts and funding have been placed into diagnostic, prevention, and treatment options. This review evaluates mRNA vaccines, their advantages, limitations, and current progress towards vaccine production. We included current methods of mRNA vaccine production and introduce potential changes in vaccine delivery methods currently being developed to specifically aid in targeting the coronavirus. We evaluated various routes of administration and their potential to allow vaccines to reach the immune system and induce an immune response to produce antibodies and provide immunity. Safety and efficacy have been evaluated in this review of various mRNA clinical trials that aimed to determine if mRNA vaccines can cause antibody production and the types of adverse events associated with them. Although mRNA vaccines are not perfect in design, the possibilities they offer in advancing vaccine research and fighting other viral infections while improving immunity are worth further research.

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Cardiovascular disease, inflammation, and mRNA stability

Cited by 4 publications

References 7 publications

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Regulation of Synthesis of Coenzyme Q10

mRNA Vaccine Review against COVID-19 with Potential Applications to Improve Efficacy and Targeting

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