Cardiovascular Adjustments After Acute Heat Exposure

Romero, Steven A.; Richey, Rauchelle E.; Hemingway, Holden W.

doi:10.1249/jes.0000000000000304

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…To study how heat exposure modulates vascular function, several studies have considered acute changes following various heating modalities. Such studies provide insights into the factors that might mediate longer‐term adaptations in response to repeated heat exposure (Romero et al., 2022 ), and they are expected to continue because there are several unanswered questions regarding the effect of heat exposure on vascular function, such as (Brunt & Minson, 2021 ): the underlying physiological modulators (e.g., shear stress vs. heat shock proteins vs. circulating factors), population differences (e.g., males/females, age, disease) and/or optimal heating parameters (e.g., duration, intensity). To date, the acute effect of heat exposure on brachial artery macro‐ and microvascular function has proved variable.…”

Section: Discussionmentioning

confidence: 99%

“…Such studies provide insights into the factors that might mediate longer-term adaptations in response to repeated heat exposure (Romero et al, 2022), and they are expected to continue because there are several unanswered questions regarding the effect of heat exposure on vascular function, such as :…”

Section: Perspectivesmentioning

confidence: 99%

“…To gain a better understanding of how heat exposure might modulate vascular function, studies have also considered the acute effect of heat exposure on FMD and/or PORH. It has been hypothesized that the cardiovascular adjustments following acute heat exposure might predict longer‐term adaptations (Romero et al., 2022 ). However, the acute effect of heat exposure on FMD and PORH has proved variable, with some studies observing an improvement in FMD (Cheng et al., 2019 , 2021 ; Coombs et al., 2021 ; Gravel et al., 2020 ; Romero et al., 2017 ; Tinken et al., 2009 ) or PORH (Cheng et al., 2021 ; Romero et al., 2017 ), whereas others did not observe an acute change in FMD (Alali et al., 2020 ; Behzadi et al., 2022 ; Brunt, Jeckell et al., 2016 ; Coombs et al., 2019 ; Engelland et al., 2020 ; Gravel et al., 2019 ; Thomas et al., 2016 ) or PORH (Behzadi et al., 2022 ; Brunt, Jeckell et al., 2016 ; Engelland et al., 2020 ; Gravel et al., 2020 , 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Chaseling

Debray

Gravel

et al. 2022

Experimental Physiology

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New Findings What is the central question of this study?Do measurement timing, heating modality and biological sex modulate the acute effect of heat exposure on brachial artery flow‐mediated dilatation and postocclusion reactive hyperaemia? What is the main finding and its importance?The acute effect of heat exposure on brachial artery flow‐mediated dilatation and postocclusion reactive hyperaemia is: (1) transient and short lasting; (2) different between forearm and whole‐body heating; (3) unaffected by forearm heating during whole‐body heating; and (4) not different but not always equivalent between males and females. These findings provide a useful basis for future studies to investigate the acute effect of heat exposure on vascular function. Abstract The aim of this study was to gain a better understanding of the acute effect of heat exposure on brachial artery flow‐mediated dilatation (FMD) and postocclusion reactive hyperaemia (PORH) by: characterizing the time course of changes post‐heating; comparing forearm and whole‐body heating; determining the impact of forearm heating during whole‐body heating; and comparing males and females. Twenty adults (11 males and nine females; 28 ± 6 years of age) underwent two forearm [10 min electric blanket (EB) or 30 min hot water immersion (WI)] and two whole‐body [60 min water‐perfused suit with forearm covered (WBH‐C) or uncovered (WBH‐U)] heating modalities. The FMD and PORH were measured before and after (≤5, 30, 60, 90 and 120 min) heating. The FMD increased from baseline 30 min after EB, and 30 and 90 min after WI. In contrast, FMD decreased from baseline immediately after both WBH modalities. Peak PORH increased immediately after WI and both WBH modalities. Total PORH did not differ after WI, whereas it decreased immediately after both WBH modalities. Covering the forearm during WBH did not alter acute changes in FMD or PORH. Changes in FMD and PORH did not differ statistically between males and females during each heating modality, although the observed differences could not always be considered equivalent. These results demonstrate that the acute effect of heat exposure on brachial artery FMD and PORH is: (1) transient and short lasting; (2) different between forearm heating and WBH; (3) unaffected by direct forearm heating during WBH; and (4) not different but not always equivalent between males and females.

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Section: Discussionmentioning

confidence: 99%

Section: Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Chaseling

Debray

Gravel

et al. 2022

Experimental Physiology

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The acute effect of whole-body heat therapy on peripheral and cerebral vascular reactivity in Black and White females

Martin

Akins

Merlau

et al. 2023

Microvascular Research

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High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue

Wang,

Chen,

Zhang

et al. 2024

Life Metabolism

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Obesity is considered an epidemic often accompanied by insulin resistance (IR). Heat treatment (HT) has been shown to prevent high-fat diet-induced IR in skeletal muscle, but the underlying mechanisms are poorly understood. In this study, we discovered that high temperature alleviated the hallmarks of obesity by promoting glycogen synthesis and lowering blood glucose levels in skeletal muscle tissue (SMT). Additionally, HT maintained the decay phase of heat shock factor 1 (HSF1), leading to the activation of gene expression of heat shock proteins (HSPs), which contributed to the alleviation of IR in SMT of diet-induced obese (DIO) mice. Metabolomics and lipidomics analyses showed that HT promoted ceramide (Cer) breakdown, resulting in an elevation of both sphingomyelin (SM) and sphingosine, which further contributed to the amelioration of IR in SMT of DIO mice. Importantly, the increase in sphingosine was attributed to the heightened expression of the acid ceramidase N-acylsphingosine amidohydrolase 1 (ASAH1), and the inhibition of ASAH1 attenuated HT-relieved IR in SMT of DIO mice. Surprisingly, high temperature increased the composition of Cer and cholesteryl ester in lipid droplets of skeletal muscle cells. This not only helped alleviate IR but also prevented lipotoxicity in SMT of DIO mice. These findings revealed a previously unknown connection between a high-temperature environment and sphingolipid metabolism in obesity, suggesting that high temperature can improve IR by promoting Cer catabolism in SMT of obese mice.

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Cardiovascular Adjustments After Acute Heat Exposure

Abstract: Numerous cardiovascular adjustments occur following passive heat exposure. These adjustments may predict the long-term adaptations associated with chronic heat therapy.

Cited by 5 publications

References 64 publications

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

The acute effect of whole-body heat therapy on peripheral and cerebral vascular reactivity in Black and White females

High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue

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