Cardioprotective potency of anthocyanin-rich extract of red cabbage against isoproterenol-induced myocardial infarction in experimental animals

Abstract

The current research was realized for the cardioprotective effect of anthocyanin-rich extract of red cabbage (ARERC) on isoproterenol-induced (ISO) myocardial infarction (MI) in rats. Total phenolic, anthocyanin content, and antioxidant activity were assessed in ARERC. ARERC acute toxicity was evaluated. The results revealed that ARERC contains a high amount of total phenolic (633.9 mg gallic acid equivalents/100 g) and total anthocyanin (618.2 mg Cy3G/100 g) in association with antioxidant activity against (1,1-diphenyl-2-picrylhydrazyl) radicals and possesses high reducing capacity. ARERC was completely safe up to 12 g/kg mice BW. ISO-induced myocardial injury was recognized by elevation in relative heart weight, plasma cardiac marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase, and alanine transaminase), oxidative stress markers (malondialdehyde, superoxide dismutase, and catalase), inflammatory marker C-reactive protein, and histological changes in the cardiac tissue. ARERC oral administration (100 and 200 mg/kg) before MI initiation diminished oxidative stress and inflammation, reinstated the cardiac antioxidants, and improved all changes in cardiac tissue in rats. ISO increased inflammatory cytokines expression (IL-6 and IL-1) and 5-hydroxytryptamine-7 receptor in the cardiac tissue. Results suggested that administration of ARERC alleviates inflammation, stress of oxidation, and damage in the cardiac tissues. Results suggested the beneficial effect of ARERC as an alternative treatment against cardiovascular diseases, especially MI.

Organotoxic Effect of Aqueous Extract of Justicia secunda Vahl. Leaf in Wistar Rats

“…The extensive inflammation seen in the heart tissues shows the cardiotoxic effect of the extract. Several tropical plant species have been reported to possess cardiotoxic effects when used as herbal remedies [17,18]. It was reported that an aqueous extract of J. traquebareinsis leaf showed cardioprotective effects against isoproterenol-induced myocardial infarction in rats.…”

Phytochemical Analysis on Aqueous Leaf Extract of Justicia carnea (Acanthaceae) and its Antibacterial Activity on Some Isolated Bacterial

“…Traditionally, Justicia carnea is used in the management of inflammation, gastrointestinal disorders, respiratory tract infection, fever, pain, diabetes, diarrhea, liver diseases, rheumatism and arthritis (Badami et al, 2003;Corrêa & Alcântara, 2012). They also possess antiinflammatory, anti-allergic, anti-tumoral, anti-viral and analgesic activities (Radhika et al, 2013).…”