2011
DOI: 10.1016/j.niox.2010.11.001
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Abstract: The gaseous mediator hydrogen sulfide (H 2 S) is synthesized mainly by cystathionine gammalyase in the heart and plays a role in the regulation of cardiovascular homeostasis. Here we first overview the state of the art in the literature on the cardioprotective effects of H 2 S in various models of cardiac injury. Subsequently, we present original data showing the beneficial effects of parenteral administration of a donor of H 2 S on myocardial and endothelial function during reperfusion in a canine experimenta… Show more

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Cited by 107 publications
(101 citation statements)
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References 46 publications
(60 reference statements)
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“…Several studies have already established its cardioprotective profile Salloum, 2015;Wang et al, 2015). In the vast majority of the cases, H 2 S salts were used to deliver H 2 S (Szabó et al, 2011;Salloum, 2015). Herein, we compared some of the most commonly used H 2 S donors in vitro and in vivo.…”
Section: Discussionmentioning
confidence: 99%
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“…Several studies have already established its cardioprotective profile Salloum, 2015;Wang et al, 2015). In the vast majority of the cases, H 2 S salts were used to deliver H 2 S (Szabó et al, 2011;Salloum, 2015). Herein, we compared some of the most commonly used H 2 S donors in vitro and in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…H 2 S donors, including diallyl disulfide and S-propargylcysteine, have been shown to rescue cultured cardiomyocytes from high glycose injury, doxorubicin-induced toxicity or ROStriggered injury (Szabó et al, 2011;Guo et al, 2013;Wu et al, 2015;Yang et al, 2015). The mechanisms through which H 2 S donors have been proposed to exerts their protective effects in these cultured cell systems include ATP-sensitive potassium channel and Akt activation, inhibition of mitogen-activated protein kinases pathways (p38, c-Jun N-terminal protein kinases), and inhibition of endoplasmic reticulum stress, as well as antioxidant mechanisms (Szabó et al, 2011;Wang, 2012;Guo et al, 2013;Salloum, 2015;Wu et al, 2015;Yang Fig.…”
Section: Discussionmentioning
confidence: 99%
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“…Furthermore, K V 7.1, K V 7.4, and K V 7.5 channels have emerged as important regulators of vascular tone (Hedegaard et al, 2014;Stott et al, 2014) and of hypoxic as well as agonist-induced vasodilatation. Adenosine and hydrogen sulfide are cardioprotective and both induce vasodilatation involving K V 7 channel opening (Elrod et al, 2007;Rossoni et al, 2008;Osipov et al, 2009;Schleifenbaum et al, 2010;Szabó et al, 2011;Khanamiri et al, 2013;Hedegaard et al, 2014). Therefore, modulation of K V 7 channels could be involved in cardiac IR injury.…”
Section: Introductionmentioning
confidence: 99%