2011
DOI: 10.1016/j.jtcvs.2010.08.064
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Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves

Abstract: In this model anti-Gal antibody accelerates calcification of wild-type but not Gal-deficient glutaraldehyde-fixed pericardium. This study suggests that preformed anti-Gal antibody present in all patients might contribute to calcification of currently used bioprosthetic heart valves. Gal-deficient pigs might become the preferred source for new, potentially calcium-resistant bioprosthetic heart valves.

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Cited by 68 publications
(72 citation statements)
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“…Despite structural and functional similarities with human myocardium and the wide use of pig heart valves in cardiovascular surgery [58], [59], there are few genome-wide experimental identifications of miRNAs in the pig heart [60]. Our analysis identified a cluster of miRNAs preferentially expressed in atrium and ventricle with some overlap with those expressed in the stomach (Figure 4 C).…”
Section: Resultsmentioning
confidence: 86%
“…Despite structural and functional similarities with human myocardium and the wide use of pig heart valves in cardiovascular surgery [58], [59], there are few genome-wide experimental identifications of miRNAs in the pig heart [60]. Our analysis identified a cluster of miRNAs preferentially expressed in atrium and ventricle with some overlap with those expressed in the stomach (Figure 4 C).…”
Section: Resultsmentioning
confidence: 86%
“…Further evidence for a link between Gal and calcification was established by McGregor et al [28] and Lila et al [29], who investigated pericardium from GTKO pigs. The GTKO pig pericardium, pre-labeled with human anti-Gal antibody, calcified less than pericardium from wild-type pigs.…”
Section: Decreasing the Immune Response To Gbhvs E The Futurementioning
confidence: 89%
“…The α-Gal-free nature of biostable polymers means lower risks of calcification compared to porcine and bovine tissues and may lead to potential advantages in terms of long-term performance and durability [38, 57, 58]. Moreover, there is no suturing involved in the manufacturing process, hence no stitch hole in the leaflets which could cause tissue tear in the flexion zones.…”
Section: Discussionmentioning
confidence: 99%