Cardiac Tumors and Associated Arrhythmias in Pediatric Patients, With Observations on Surgical Therapy for Ventricular Tachycardia

Miyake, Christina Y.; Nido, Pedro J. del; Alexander, Mark E.; Cecchin, Frank; Berul, Charles I.; Triedman, John K.; Geva, Tal; Walsh, Edward P.

doi:10.1016/j.jacc.2011.08.005

Cited by 173 publications

(185 citation statements)

References 28 publications

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“…11 In addition, SEER includes only patients diagnosed with cancer before death, not postmortem findings. Although PMCTs commonly present with dyspnea, chest pain, palpitations, and edema, [11][12][13] they can also remain clinically silent until causing ventricular arrhythmias 13 and sudden cardiac death, 14 thus escaping inclusion in SEER. Nevertheless, more in line with our findings, a recent study in Grosseto's county in Italy (1998-2011) estimated the incidence of PMCTs at ≈130 per 100 million persons.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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Background-The aim of this study was to investigate the incidence, histopathology, demographics, and survival associated with primary malignant cardiac tumors (PMCTs). Methods and Results-We queried the Surveillance, Epidemiology and End Results (SEER) 18 registry from the National Cancer Institute for all PMCTs diagnosed from 1973 to 2011. We describe PMCT histopathology and incidence, comparing characteristics and survival of these patients with those of patients with extracardiac malignancies of similar histopathology. From a total of 7 384 580 cases of cancer registered in SEER, we identified 551 PMCTs (0.008%). The incidence of PMCT diagnosis is 34 cases per 100 million persons and has increased over time (25.1 in 1973-1989, 30.2 in 1990-1999, and 46.6 in 2000-2011). Most patients are female (54.1%) and white (78.6%) with median age at diagnosis of 50 years. The most common PMCTs are sarcomas (n=357, 64.8%), followed by lymphomas (n=150, 27%) and mesotheliomas (n=44, 8%). Most patients are diagnosed with tissue sample (96.8%). Although use of chemotherapy is not documented in SEER, 19% of patients received radiation and 44% had surgery. After a median follow-up of 80 months, 413 patients had died. The 1-, 3-, and 5-year survival rates were 46%, 22%, and 17% and have improved over the eras, with 1-, 3-, and 5-year survival rates of 32%, 17%, and 14% for 1973 to 1989 and 50%, 24%, and 19% for 2000 to 2011 (P=0.009). Cardiac sarcomas and mesotheliomas are the most lethal PMCTs, with 1-, 3-, 5-year survival rates of 47%, 16%, and 11% and of 51%, 26%, and 23% compared with 59%, 41%, and 34% for lymphomas, respectively (log rank test P<0.001). Patients with cardiac lymphomas and sarcomas are younger and have worse survival than patients with extracardiac disease of similar histopathology (P<0.001). Conclusions-PMCTs are extremely rare and continue to be associated with poor prognosis. Over the past 5 decades, the incidence and survival of patients diagnosed with PMCT appear to have increased.

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Section: Discussionmentioning

confidence: 99%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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“…It has previously been reported that cardiac metastatic tumors may result in complete atrioventricular block (11,12) and VT (13,14). Myocardium surrounded or infiltrated by metastatic tumor may manifest abnormal electrophysiological properties (15) and manifested as increased automaticity due to triggered activity, however, severity of myocardial infiltration surrounding the metastatic tumor was not homogeneous and resulted in complicated form of VT with variant ECG morphology and heart rate. The dominant activation pattern was irregular and randomly fluctuated between the anterior free wall and the septum of the RVOT.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation of metastatic chondrosarcoma-associated refractory ventricular tachycardia originating from the right ventricular outflow tract: A case report and literature review

Shi¹,

Liang²,

Li³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Ventricular tachycardia (VT) and premature contraction originating from the right ventricular outflow tract (RVOT) usually appear in healthy individuals. Radiofrequency ablation (RFA) is highly effective at resolving this type of arrhythmia. Refractory VT of RVOT is uncommon and occasionally results from cardiac metastasis of extraskeletal mesenchymal chondrosarcomas (ESMC). ESMC is a rare malignant tumor arising from soft tissues. The current study presents the case of a 25-year-old male with severe VT arising from RVOT due to metastasis of an ESMC that originally occurred in the retroperitoneum. The diagnosis was confirmed following echocardiography and cardiac magnetic resonance. VT was eventually eliminated by RFA, and during the 8-month follow-up period the patient did not complain of any palpitations. Holter monitoring confirmed the absence of recurrence.

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“…9,10 Monomorphic ventricular tachycardia is one of the most frequently reported types of cardiac metastasis-related ventricular arrhythmia in both children and adults. [11][12][13][14] In contrast, polymorphic ventricular tachycardia (PMVT) in the setting of cardiac metastasis has been reported only once. 15 We describe an adult patient who presented with sustained PMVT as a manifestation of metastatic melanoma, and review the manifestations and consequences of cardiac involvement of melanoma.…”

Section: Introductionmentioning

confidence: 99%

An Uncommon Presentation for Cardiac Melanoma

Baykalır¹,

Young²,

Slosky³

et al. 2014

Journal of Patient-Centered Research and Reviews

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Journal of Patient-Centered Research and Reviews ( JPCRR) is a peerreviewed scientific journal whose mission is to communicate clinical and bench research findings, with the goal of improving the quality of human health, the care of the individual patient, and the care of populations. Recommended Citation An Uncommon Presentation for Cardiac Melanoma AbstractA 66-year-old man with locally advanced malignant melanoma, which was surgically resected, presented with a 3-week history of dizziness, recurrent near-syncopal episodes and generalized weakness. He was found to have sustained polymorphic ventricular tachycardia in the setting of cardiac melanoma. We draw attention to an unusual presentation of malignant melanoma with cardiac metastasis and discuss both its etiology and treatment options. (J Patient-Centered Res Rev. 2014;1:128-132.)

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Cardiac Tumors and Associated Arrhythmias in Pediatric Patients, With Observations on Surgical Therapy for Ventricular Tachycardia

Abstract: Clinically significant arrhythmias occurred in 24% of pediatric patients with cardiac tumors, VT being the most common type. Surgical excision for VT associated with rhabdomyomas and fibromas in selected patients is an important and effective management strategy in these patients.

Cited by 173 publications

References 28 publications

Characteristics and Survival of Malignant Cardiac Tumors

Characteristics and Survival of Malignant Cardiac Tumors

Radiofrequency ablation of metastatic chondrosarcoma-associated refractory ventricular tachycardia originating from the right ventricular outflow tract: A case report and literature review

An Uncommon Presentation for Cardiac Melanoma

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