Cardiac toxicity of heavy metals (cadmium and mercury) and pharmacological intervention by vitamin C in rabbits

Ali, Shaukat; Awan, Zubia; Mumtaz, Sadaf; Shakir, Hafiz Abdullah; Ahmad, Farooq; Ulhaq, Mazhar; Tahir, Hafız Muhammad; Awan, M. S.; Sharif, Saima; Irfan, Muhammad; Khan, Muhammad Azmat Ullah

doi:10.1007/s11356-020-09011-9

Cited by 47 publications

(19 citation statements)

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“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies (Ali et al, 2020a;Ali et al, 2020b;Hussain et al, 2020;Ara et al, 2020;Ali et al, 2019;Khan et al, 2019;Mumtaz et al, 2019;Mughal et al, 2019;Dar et al, 2019) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Ethical Statementmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

PeerJ

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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

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Section: Ethical Statementmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

PeerJ

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Ethical Statementmentioning

confidence: 99%

Peer Review #3 of "Silk derived formulations for accelerated wound healing in diabetic mice (v0.2)"

2021

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Background: The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods: Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis.Results: The results indicated that the best biocompatible silk combination was of 5 % silk fibroin and 5 % Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5±0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion: It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

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“…生素 C [56] ，红景天提取物 [61] ，大蒜素 [68] 都能对于镉金属中毒导致的心肌损伤产 [56] 。小鼠体内的类似实验同样验证了维生素 C 的这一作用 [69] 。 [61] 。大蒜素主要通过激活 eNOS、SOD-1 和-2、Bcl-2 基因的表达，降低 NF-κB、 IL-17A、Bax、caspases-3 和 caspases -9 基因的表达，能有效减轻代谢综合征模型大鼠的心肌缺血再灌注损伤，对离体心肌缺血再灌注损伤具有保护作用，产生有助于心肌修复的蛋白 MT [68,70] 。除此之外还有像维生素 E [71] ，芝麻种子提取物 [72] ，牛磺酸镁 [73] ，人工合成药物罗氟司特 [74] 、卡维地洛 [64] ，褪黑素 [75] [34] ，然而其分子机制尚未明确，因此镉如何导致血清中脂类物质代谢异常还有待解决。目前关于血液循环中的低密度脂蛋白是如何进入动脉壁而引发动脉粥样硬化 [51] 在机制上还不明确。抑制内皮细胞向动脉壁输送低密度脂蛋白的干预可能是对抗心血管疾病的一个新的治疗策略。同时，降低动脉粥样硬化程度的研究还有抑制相关脂代谢蛋白的降解 [80] ，提高或降低相关基因的表达 [81] 等方式。关于镉在凝血功能方面的危害，有观点认为，镉能通过影响纤维蛋白原水平和凝血酶时间导致凝血功能异常。但在有些报道中指出，镉中毒的大鼠血液中血小板明显下降，凝血时间延长，伴随纤维蛋白原降低的现象 [82] ，其中的原因有待进一步研究。环境污染的生物治理以微生物的筛选为研究中心 [83] ，因为微生物与其生活的环境有着重要的相关性。有关于肠道微生物与人体健康相关性的的研究指出，有益的肠道微生物可产生抗炎因子、缓解疼痛的化合物、抗氧化剂和维生素，对机体供给营养并提供保护。有害的肠道微生物可能会使介导能量代谢的基因失控，产生毒素致使 DNA 突变，进而影响神经和免疫系统。据报道，多种形式的慢性病(包括肥胖，糖尿病) ，与肠道稳态的破坏有直接联系 [84] 。重金属导致的疾病多为慢性病，是否可以通过移植菌群达到改变肠道环境，进而降低慢性病的危害，值得进一步探讨。镉暴露对不同性别间的危害可能存在差异。有实验结果指出，在低剂量镉暴露的条件下，脂代谢的变化只能在雄性小鼠中观测到，而非雌性小鼠中 [77] 。这可能是由于雌性小鼠的非核雌激素受体激活，从而改善了其体内的肝脏脂肪变性情况 [85] 。对于孕妇群体，如何识别环境对胎儿的影响，又如何安全有效治疗孕妇和胎儿因环境刺激而产生的疾病，非常值得关注。据报道，怀孕小鼠接触镉，会从脐带进入后代体内造成出现镉中毒现象 [86] ；怀孕小鼠吸烟，后代也会出现肺损伤 [87] [11,[88][89][90] 十分必要且具有现实意义，相关实验包括关于水体污染物对水产品的影响 [91] ，空气污染物对各种生物体的影响，这类实验更加贴近实际生产生活。研究关于环境污染对人类健康的影响，并投入行之有效的解决方案是关键，相关思路见图四。图四：环境污染与人类健康的研究展望包括重金属在内的诸多环境污染物严重影响了人类的身心健康，尤其对于某些易感人群而言，暴露于污染环境下，危险性不言而喻。如何有针对性地保护这些易感人群，对于科学研究而言具有重要的意义。 Figure 4: Research prospect on environmental pollution and human health Many environmental pollutants, including heavy metals, severely affect the human health physically and mentally, particularly that of susceptible individuals. The harmfulness of exposure to polluted environment is incontestable.…”

Section: 通过天然产物有效成分缓解镉的心脏毒性在中外医学的相关研究中，生物天然代谢产物常用于新药开发。据报道，维unclassified

Potential mechanism and treatment of heavy metal cadmium-induced cardiovascular disease

Li¹,

Zhong²,

Guo³

2021

Sci. Sin.-Vitae

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Heavy metals are common environmental pollutants. Owing to their strong binding ability, they are extremely harmful to the human body and have become a research topic garnering extensive interest in the study of environmental pollutants.Nowadays, cardiovascular diseases have the highest morbidity and mortality worldwide, which severely affect human health. Long-term exposure to heavy metal-containing environments greatly increases the incidence rate of cardiovascular diseases. This article aims to discuss the toxicity of cadmium, which exhibits the most obvious effect on the heart, and present the relevant mechanisms of cadmium poisoning-induced cardiovascular diseases. Current and future feasible treatment strategies have also been prospected and summarized.

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Cardiac toxicity of heavy metals (cadmium and mercury) and pharmacological intervention by vitamin C in rabbits

Cited by 47 publications

References 65 publications

Silk derived formulations for accelerated wound healing in diabetic mice

Silk derived formulations for accelerated wound healing in diabetic mice

Peer Review #3 of "Silk derived formulations for accelerated wound healing in diabetic mice (v0.2)"

Potential mechanism and treatment of heavy metal cadmium-induced cardiovascular disease

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