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“…The concept of continuous normothermic blood cardioplegia to achieve diastolic arrest was first proposed by Gott et al in 1957 5,6 . Many years later, in the late 1980s, my basic science laboratory in Toronto was very active, with many students pursuing higher degrees with a variety of investigative projects.…”
Section: Conceptual Framework Of Warm Blood Cardioplegiamentioning
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“…The concept of continuous normothermic blood cardioplegia to achieve diastolic arrest was first proposed by Gott et al in 1957 5,6 . Many years later, in the late 1980s, my basic science laboratory in Toronto was very active, with many students pursuing higher degrees with a variety of investigative projects.…”
Section: Conceptual Framework Of Warm Blood Cardioplegiamentioning
“…The first use of "elective cardiac arrest" was by Melrose in 1955, who also coined the term "cardioplegia" for the technique [5]. Gott et al used retrograde perfusion of the heart via the coronary sinus using warm blood with Melrose solution [6]. Lillehei's group also used retrograde perfusion of the coronary sinus with blood during aortic valve surgery [7].…”
Section: Historical Aspectsmentioning
“…introduced the concept of chemical cardioplegia into cardiac surgery . Gott et al., working at Lillehei's laboratory at the University of Minnesota, demonstrated the beneficial effects of continuous retrograde normothermic blood cardioplegia in dogs , leading to what is currently known as “warm heart surgery.” Subsequently, they used a very high potassium cardioplegic solution to arrest the heart, which led to severe myocardial damage, causing abandonment of normothermic potassium cardioplegia. Hypothermia continued to dominate the field of myocardial protection and played a major role in the history and the development of the specialty.…”
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