Cardiac output measurement by pulse dye densitometry: a comparison with the Fick's principle and thermodilution method

Bremer, Frank; Schiele, A.; Tschaikowsky, K.

doi:10.1007/s00134-002-1252-3

Cited by 26 publications

(22 citation statements)

References 19 publications

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“…Increased overestimation occurred, particularly in the low cardiac output range (cardiac output < 3.5 l.min . These results could not be confirmed by other investigators who compared pulse dye densitometry with thermodilution cardiac output in cardiac surgery patients after admission to the intensive care unit using the simultaneous injection method [9,11,13]. In contrast to our study, Imai et al used a nose probe to detect indocyanine green concentrations [12].…”

Section: Discussioncontrasting

confidence: 99%

“…, and our results correspond nicely with those published by Bremer et al [13] for cardiac output values < 5 l.min . Some investigators have used indocyanine green concentrations ranging from 5 to 30 mg per bolus injection to assess the accuracy and precision of pulse dye densitometry in comparison with invasive methods.…”

Section: Discussionsupporting

confidence: 93%

“…The best agreement between pulse dye densitometry and thermodilution was reported by Bremer et al [13], but the technique was only found to be reliable at cardiac output values > 5.0 l.min . The corresponding values for bias and precision at cardiac output > 5.0 l.min )1 were ) 0.29 l.min )1 and ± 1.14 l.min…”

Section: Discussionmentioning

confidence: 90%

“…Performance was particularly poor in the ICU, where the signals were low or absent in > 50% of the patients. Conflicting reports have been published on the accuracy of pulse dye densitometry [7,9,[11][12][13][14]21]. Bühlmann et al [11] and Imai et al [12] reported a satisfactory agreement between pulse dye densitometry and thermodilution, but the results of the Bland-Altman analysis do not justify their conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Pulse dye densitometry is based on the principle of indocyanine green dye dilution, whereby indocyanine green is injected through a central [7] or peripheral [8] venous line and the changes in dye concentration over time are detected by pulse spectrophotometry using a finger probe [7,9] or a nose probe [10,11]. Only a few investigators [7,[12][13][14] have compared pulse dye densitometry with standard methods of cardiac output determination, and the accuracy of pulse dye densitometry is therefore in dispute.Our primary aim was to validate pulse dye densitometry in patients before and after elective coronary artery bypass graft surgery (CABG). Our secondary aim was to investigate whether different concentrations of indocyanine green would affect the accuracy of pulse dye densitometry.…”

mentioning

confidence: 99%

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Cardiac output measurement by pulse dye densitometry in cardiac surgery

Baulig¹,

Bernhard²,

Béttex³

et al. 2005

Anaesthesia

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SummaryThe aim of this study was to compare the accuracy of pulse dye densitometry with that of bolus thermodilution cardiac output measurement in patients before and after elective coronary artery bypass grafting. Twenty-eight patients were studied. Agreement between mean thermodilution and pulse dye densitometry cardiac output values was assessed by Bland-Altman analysis. [2.0-7.2] l.min )1 for pulse dye densitometry using indocyanine green 20 mg. Mean bias was + 0.566 l.min )1 , the limits of agreement were ± 2.51 l.min )1 and mean error was 60.9%. Postoperative cardiac output data were not analysed because pulse dye densitometry signals were low or absent in > 50% of the patients. We conclude that pulse dye densitometry using indocyanine green 5 mg or 20 mg is inaccurate in anaesthetised patients before coronary artery bypass surgery and cannot be used after surgery because of a high incidence of low pulse dye densitometry signal amplitudes. Pulse dye densitometry is based on the principle of indocyanine green dye dilution, whereby indocyanine green is injected through a central [7] or peripheral [8] venous line and the changes in dye concentration over time are detected by pulse spectrophotometry using a finger probe [7,9] or a nose probe [10,11]. Only a few investigators [7,[12][13][14] have compared pulse dye densitometry with standard methods of cardiac output determination, and the accuracy of pulse dye densitometry is therefore in dispute.Our primary aim was to validate pulse dye densitometry in patients before and after elective coronary artery bypass graft surgery (CABG). Our secondary aim was to investigate whether different concentrations of indocyanine green would affect the accuracy of pulse dye densitometry. The accuracy of cardiac output determination by pulmonary thermodilution has been assessed and confirmed at our institution [15]. MethodsWith the approval of the Local Research Ethics Committee and written, informed consent, 28 patients who were scheduled for elective CABG were enrolled in the study. Exclusion criteria comprised: allergy to iodine, presence of an aortic counterpulsation device, severe renal disease or liver dysfunction and intake of drugs with a Anaesthesia, 2005, 60, pages 968-973

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cardiac output measurement by pulse dye densitometry in cardiac surgery

Baulig¹,

Bernhard²,

Béttex³

et al. 2005

Anaesthesia

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In vivo multispectral photoacoustic and photothermal flow cytometry with multicolor dyes: A potential for real‐time assessment of circulation, dye‐cell interaction, and blood volume

Проскурнин¹,

Zhidkova²,

Volkov³

et al. 2011

Cytometry Pt A

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Recently, photoacoustic (PA) flow cytometry (PAFC) has been developed for in vivo detection of circulating tumor cells and bacteria targeted by nanoparticles. Here, we propose multispectral PAFC with multiple dyes having distinctive absorption spectra as multicolor PA contrast agents. As a first step of our proof-of-concept, we characterized high-speed PAFC capability to monitor the clearance of three dyes (ICG, MB, and TB) in an animal model in vivo and in real time. We observed strong dynamic PA signal fluctuations, which can be associated with interactions of dyes with circulating blood cells and plasma proteins. PAFC demonstrated enumeration of circulating red and white blood cells labeled with ICG and MB, respectively, and detection of rare dead cells uptaking TB directly in bloodstream. The possibility for accurate measurements of various dye concentrations including CV and BG were verified in vitro using complementary to PAFC photothermal (PT) technique and spectrophotometry under batch and flow conditions. We further analyze the potential of integrated PAFC/PT spectroscopy with multiple dyes for rapid and accurate measurements of circulating blood volume without a priori information on hemoglobin content, which is impossible with existing optical techniques. This is important in many medical conditions including surgery and trauma with extensive blood loss, rapid fluid administration, transfusion of red blood cells. The potential for developing a robust clinical PAFC prototype that is, safe for human, and its applications for studying the liver function are further highlighted.

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Less Invasive Cardiac Output Monitoring: Characteristics and Limitations

Hofer

Zollinger

2006

Intensive Care Medicine

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Cardiac output measurement by pulse dye densitometry: a comparison with the Fick's principle and thermodilution method

Cited by 26 publications

References 19 publications

Cardiac output measurement by pulse dye densitometry in cardiac surgery

Cardiac output measurement by pulse dye densitometry in cardiac surgery

In vivo multispectral photoacoustic and photothermal flow cytometry with multicolor dyes: A potential for real‐time assessment of circulation, dye‐cell interaction, and blood volume

Less Invasive Cardiac Output Monitoring: Characteristics and Limitations

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