Cardiac Manifestations of Q Fever Infection: Case Series and a Review of the Literature

Gunn, Moses; Raz, Meir; Turek, Joseph W.; Farivar, Robert Saeid

doi:10.1111/jocs.12098

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…The most frequently reported persistent infection in children is osteomyelitis, which is frequently multifocal, with evidence of granulomatous bone lesions (577)(578)(579)(580)(581)(582)(583). Cases of endocarditis have been described mainly in children with congenital heart disease (187,310,615). One case of infection of a bovine jugular vein conduit graft (616) and one case of multiple recurrent abscesses (617) have also been described.…”

Section: Burnetii Infection In Special Populations: Pregnant Womenmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Burnetii Infection In Special Populations: Pregnant Womenmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…Both Q fever diseases (acute as well as chronic C. burnetti infecion) may produce important organs disturbs, including pericarditis [4]. Acute and recurrent pericarditis remains aetiologically unexplained in over 80% of cases [5].…”

Section: Introductionmentioning

confidence: 99%

Acute Pericarditis due to Coxiellaburnetiiinfection, a case report

et al. 2018

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Q fever is a worldwide zoonosis caused by Coxiella burnetii. Looking to the duration of the disease, Q fever may be divided into acute and chronic forms. In humans, acute C. burnetii is often asymptomatic or mistaken for an influenza-like illness or atypical pneumonia. On the other hand, chronic Q fever is characterized by a spontaneous evolution lasting for > 6 months and a high level of IgG antibodies titre, generally determined by the indirect fluorescence antibody (IFA). However, other clinical manifestations may be observed, including hepatic, neurologic, dermatologic, and cardiac disturbs. Teha last one includes pericarditis, which has been observed in 1% of patients affected by C. burnetii infection. However, this incidence is probably underestimated. In fact, over 80% of acute as well as recurrent pericarditis remains aetiologically unexplained.We describe a case of a 36-year-old man reporting progressive onset of dyspnea, chest pain and dysthermia sensation. Ambulatory treatment was unsatisfactory developing a severe respiratory failure recquiring his admission in the Critical Care Department. Blood test showed discrete leukocytosis with left deviation and increased reactive protein C levels. Thoracic computed tomography (CT) showed a 22mm pericardial effusion with a bilateral pleural effusion more marked in the left lung area. Microbiological as well as serological studies showed positive IgM titers to C. Burnetii. Doxycycline treatment was initiated with postive results.

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“…Chronic Q-fever, which occurs in 5-15 % of cases, leads to more severe disease involving the cardiovascular system, liver-and lung-tissue [12,13]. When cardiac involvement occurs it is often associated with substantial tissue damage in heart valves especially when valve disease is already present [14,15]. Clinical outcome following surgical repair has substantial mortality [11,14].…”

Section: Discussionmentioning

confidence: 99%

Rapid molecular diagnosis of infective aortic valve endocarditis caused by Coxiella burnetii

et al. 2016

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We describe a case of Q-fever endocarditis with severe destruction of the aortic valve with perivalvular abscess formation and cardiac failure. The patient needed urgent operative treatment and postoperative critical care. All specimens sent for microbiological examination were negative. Molecular analysis, including fluorescence in situ hybridization of aortic valve tissue combined with PCR and sequencing, led to the correct diagnosis and to appropriate anti-infective treatment. The patient subsequently recovered from complex cardiovascular surgery. This is the first report on Q-fever endocarditis that was rapidly diagnosed using these methods.

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Cardiac Manifestations of Q Fever Infection: Case Series and a Review of the Literature

Abstract: Three patients with Q fever were successfully treated at our institution, including the first known case of a C. burnetii infection manifesting in a pediatric patient with isolated aortic coarctation.

Cited by 13 publications

References 33 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Acute Pericarditis due to Coxiellaburnetiiinfection, a case report

Rapid molecular diagnosis of infective aortic valve endocarditis caused by Coxiella burnetii

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