Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease

Milovanovic, Branislav; Filipović, Branka; Mutavdzin, Slavica; Zdravković, Marija; Gligorijevic, Tatjana; Paunovic, Jovana; Arsic, Marina

doi:10.3748/wjg.v21.i22.6982

Cited by 22 publications

(19 citation statements)

References 24 publications

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“…The results of this study suggest a significant improvement in several parameters of HRV following a healing treatment of PPI therapy in individuals with ERD. This is consistent with other reported studies looking at patients with GERD, e.g., Milovanovic et al 16 This statistically significant improvement in HRV was not observed in the NERD group. This is in spite of there being no difference between the reported symptom impact scores in the two groups following PPI therapy, indicating that both groups recorded a similar symptomatic benefit from the PPI therapy.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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The effects of proton pump inhibitors on autonomic tone in patients with erosive and non‐erosive esophagitis

Jones

Perring

Khattab

et al. 2016

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

The effects of proton pump inhibitors on autonomic tone in patients with erosive and non‐erosive esophagitis

Jones

Perring

Khattab

et al. 2016

Neurogastroenterology Motil

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show abstract

“…17 However, other studies done by Elewa et al and Milovanovic et al found no significant differences in DBP response to Sustained Handgrip test in patients with GERD than in control group. 18,19 The probable reason of the present findings is due to the decreased sympathetic activity. Reduced sympathetic activity can cause intrinsic inhibitory reflex disturbances and increased number and time duration of TLESRs episodes resulting in pathological enhancement of GERD.…”

Section: Discussionmentioning

confidence: 65%

Cardiovascular response to sustained handgrip test in gastroesophageal reflux disease patients

Sogan

Mathur

Sankhla

2016

Int J Community Med Public Health

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Background: Gastroesophageal reflux disease pathogenesis may be associated with disturbances of the autonomic nervous system.Methods: One hundred five participants aged 35-45 years of either sex, which include Gastroesophageal reflux disease patients, thirty five each (who presented typical symptom of Gastroesophageal reflux disease with reflux esophagitis (ERD) and without reflux esophagitis (NERD)) and thirty five age and sex matched control subjects, were enrolled in the study. Autonomic function test was assessed using Sustained Handgrip test.Results: In the present study, no significant difference was observed in age, height, weight, body mass index, resting systolic blood pressure and diastolic blood pressure between the study groups. The mean difference of diastolic blood pressure (mmHg) response to Sustained Handgrip test between ERD and NERD; ERD and Control; NERD and Control was statistically highly significant (p=0.001; p<0.001; p=0.029, respectively), predicting reduced sympathetic activity in gastroesophageal reflux disease, more in patients with reflux esophagitis (ERD).Conclusions: Reduced sympathetic activity can cause impairment of lower esophageal sphincter function, particularly of the neural mechanisms related to control of transient lower esophageal sphincter relaxation. It might increase number and time duration of transient lower esophageal sphincter relaxations resulting in pathological enhancement of GERD.

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“…Previous studies have shown that patients with GERD have potential imbalance of autonomic nervous system, especially impaired parasympathetic function appears more congruent to GERD . It may provide the pathophysiological basis for therapeutic intervention for GERD.…”

Section: Discussionmentioning

confidence: 96%

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

Liu

Guo

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease

Cited by 22 publications

References 24 publications

The effects of proton pump inhibitors on autonomic tone in patients with erosive and non‐erosive esophagitis

The effects of proton pump inhibitors on autonomic tone in patients with erosive and non‐erosive esophagitis

Cardiovascular response to sustained handgrip test in gastroesophageal reflux disease patients

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

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