Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy

Blanco, Angel I.; Chao, K. A.; Özyiğit, Gökhan; Adlı, Mustafa; Thorstad, Wade L.; Simpson, Joseph R.; Spector, Gershon J.; Haughey, Bruce H.; Pérez, Carlos A.

doi:10.1016/j.ijrobp.2003.09.101

Cited by 104 publications

(75 citation statements)

References 27 publications

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“…The overall survival rate was 0% and 52% respectively for patients treated with RT alone vs. surgery and postoperative RT. Blanco et al [2] in 106 patients noted a statistically significant improvement in the disease free survival in the patients receiving combined modality treatment compared to those receiving radiation alone (35% vs 29%; P<0.05). There seems to be a consensus that single modality treatment is not enough for T 3 -T 4 squamous cell carcinoma of the maxillary sinus.…”

Section: Discussionmentioning

confidence: 96%

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Squamous cell carcinoma of the maxillary sinus: A Tata Memorial Hospital experience

et al. 2006

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Section: Discussionmentioning

confidence: 96%

“…[1][2][3][4] Firstly they often present in advanced stages. Secondly the complex anatomy and the close proximity of critical structures compromise effectual surgical excision and radiation deliverance.…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of the maxillary sinus: A Tata Memorial Hospital experience

et al. 2006

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“…On the other hand, our study has some limitations. We examined cancer patients with a variety of pathological findings, similar to most previous studies on NCPS cancers [2,[16][17][18][19], because NCPS cancer is rare and accounts for only 5% of all head-and-neck cancers [20]. Also, the total irradiation dose or timing of the CT examination was not necessarily constant in our retrospective analysis.…”

Section: Discussionmentioning

confidence: 99%

Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy

Fukumitsu

Ishikawa

Ohnishi

et al. 2014

Radiotherapy and Oncology

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“…These lesions may arise from various histologic components of the sino-nasal tract, such as the Schneiderian mucosa, minor salivary glands, neural tissue, and lymphatics, all of which give rise to a heterogeneous group of disease [6]. Majority of these tumors (60 %) arise from the maxillary sinus, with 20 % arising from the nasal cavity, 5 % from the ethmoid sinuses, and 3 % from the sphenoid and frontal sinuses [2,7]. Squamous cell carcinoma followed by salivary gland tumors is the most frequent neoplasm encountered (55 %), followed by non-epithelial tumors (20 %) and glandular tumors (15 %) [8,9].…”

Section: Discussionmentioning

confidence: 99%

Management of Sinonasal Tumors: Prognostic Factors and Outcomes: A 10 Year Experience at a Tertiary Care Hospital

Kazi

Awan

Junaid

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.Keywords Sinonasal malignancy Á Locoregional recurrence Á Squamous cell carcinoma Á Positive neck nodes Malignant lesions involving the sino-nasal tract account for 0.2-0.8 % overall and 3 % of all head and neck malignancies [1]. Approximately 55 % of these lesions are carcinomas with involvement of neck nodes in 7-15 % of the conditions. Treatment involves a wide variety of modalities, including surgery, radiotherapy, and chemotherapy, alone or in combination, however, there is still great controversy about the ideal treatment [1,2]. In 2003, the American Joint Committee on Cancer (AJCC) published the sixth edition of the sino-nasal tumor staging system [3]. This was in contrast to the fifthedition staging system of sino-nasal cancer in which the surgically resectable tumors and non-resectable tumors were all grouped together in the T4 stage [4]. As a result it was difficult to evaluate the results of surgery and a newer staging system was introduced.Despite these improvements, the fact is that there is no widely accepted staging system for tumors of the nasal cavity and ethmoid/sphenoid sinuses. The AJCC tumor stage classification only includes the maxillary sinus [5]. As obvious, this proves difficulties in tumors involving multiple sites in which the primary originating site is difficult to identify.We analysed retrospectively our 10 years experience of managing sino-nasal tumors, with a series of 63 patients.

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Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy

Cited by 104 publications

References 27 publications

Squamous cell carcinoma of the maxillary sinus: A Tata Memorial Hospital experience

Squamous cell carcinoma of the maxillary sinus: A Tata Memorial Hospital experience

Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy

Management of Sinonasal Tumors: Prognostic Factors and Outcomes: A 10 Year Experience at a Tertiary Care Hospital

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