Carcinoid Tumors of the Lung and Multimodal Therapy

Divisi, Duilio; Crisci, Roberto

doi:10.1055/s-2005-837539

Cited by 36 publications

(29 citation statements)

References 12 publications

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“…The difference in survival for patients with typical and atypical carcinoid tumors has been documented. In one study, the 3-and 5-year survival was 100 and 81%, respectively, for typical tumors, and 96 and 68%, respectively, for atypical tumors (8). Similar findings were also found in another study focusing on the survival of patients with liver metastases; patient survival varied from 16 to 51 months (4).…”

Section: Discussionsupporting

confidence: 69%

“…Neuroendocrine tumors of the lung are classified into well differentiated, typical and atypical carcinoids and a poorly differentiated subgroup which includes large-cell neuroendocrine carcinomas and small-cell carcinomas; the latter of which are well known for their aggressive behavior (8). According to the WHO classification (2), typical and atypical carcinoids differ in the number of mitoses (<2 per 10 HPF vs. 2-10 per 10 HPF), in nuclear polymorphism which is either absent or present, in the percentage of lymph node metastasis which is either low or high, and in the occurrence of either rare or common metastatic disease, at presentation, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Lung carcinoid tumor biology: Treatment and survival

Stathopoulos¹

2009

Oncol Rep

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Lung carcinoid tumor biology: Treatment and survival

Stathopoulos¹

2009

Oncol Rep

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“…In a previous study of bronchial carcinoid tumors, serum tumor marker negative bronchial carcinoid tumors were also reported (17). The levels of serum neuron-specific enolase were normal in 20% of patients and those of serum carcinoembryonic antigen were normal in all patients (17).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Endobronchial Carcinoid Tumor and Sarcoidosis

et al. 2010

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Sarcoidosis is an inflammatory disease of unknown cause which is characterized by the presence of noncaseating granulomas. The association of sarcoidosis with malignancy has been an issue and remains controversial. We herein report endobronchial carcinoid tumor in a patient with sarcoidosis diagnosed by nasal mucosal biopsy, excisional biopsy of cervical lymph nodes and mediastinal lymph node dissection.

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“…With this in mind, preoperative staging of TC and AC, with specific attention to lymph node status, is very important, especially when treating patients with minimal invasive techniques like EBT, as lymph nodes are not sampled during this technique. With a specificity of 90–93% for the assessment of nodal involvement in patients with bronchial carcinoids, a preoperative CT scan is a reliable tool for excluding lymph node involvement before EBT, and is therefore mandatory in the workup for patients with bronchial carcinoid tumors [13, 27]. In this study we used 2 years as a cutoff point to define successful EBT and experienced a very low total recurrence rate of 5%.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Treatment for Bronchial Carcinoid: Patient Selection and Predictors of Outcome

et al. 2018

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Background: Traditionally, surgical resection is the preferred treatment for typical carcinoids and atypical carcinoids located in the lungs. Recently however, several studies have shown excellent long-term outcome after endobronchial treatment of carcinoid tumors located in the central airways. This study investigates clinical and radiological features as predictors of successful endobronchial treatment in patients with a bronchial carcinoid tumor. Objectives: To identify clinical and radiological features predictive of successful endobronchial treatment in patients with bronchial carcinoid. Methods: This analysis was performed in a cohort of patients with typical and atypical bronchial carcinoid referred for endobronchial treatment. Several patient characteristics, radiological features, and histological grade (typical or atypical carcinoid) were tested as predictors of successful endobronchial treatment. Results: One hundred and twenty-five patients with a diagnosis of bronchial carcinoid underwent endobronchial treatment. On multivariate analysis, a tumor diameter <15 mm (odds ratio 0.09; 95% confidence interval 0.02–0.5; p = <0.01) and purely intraluminal growth on computer tomography (CT scan) (odds ratio, 9.1; 95% confidence interval 1.8–45.8; p = <0.01) were predictive of radical endobronchial treatment. The success rate for intraluminal tumors with a diameter <20 mm was 72%. Conclusions: Purely intraluminal disease and tumor diameter on CT scan seem to be independent predictors for successful endobronchial treatment in patients with bronchial carcinoid. Based on these data, patients with purely intraluminal carcinoid tumors with a diameter <20 mm on CT scan are good candidates for endobronchial treatment, regardless of histological grade. In contrast, all patients with a tumor diameter ≥20 mm should be directly referred for surgery.

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Carcinoid Tumors of the Lung and Multimodal Therapy

Abstract: Long-term survival is based on histological completeness of surgical treatment. Octreotide scintigraphy and SPECT document N (1) and N (2) precisely.

Cited by 36 publications

References 12 publications

Lung carcinoid tumor biology: Treatment and survival

Lung carcinoid tumor biology: Treatment and survival

Concurrent Endobronchial Carcinoid Tumor and Sarcoidosis

Endobronchial Treatment for Bronchial Carcinoid: Patient Selection and Predictors of Outcome

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