Carcinogenicity study of lindane in the mouse

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…These results were confirmed by Thorpe and Walker (1973) who also observed lung metastases, which leaves no doubt as to the malignancy of these tumors. In a more recent long-term feeding study, Weisse and Herbst (1977) did not notice tumorigenic effects in Chbi NMRI (SPF) mice. In this latter experiment, besides the high spontaneous incidence of liver adenomas, the doses used were considerably lower than in previous studies, i.e., 1,2,5,25, and 50 ppm/80 weeks.…”

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…These results were confirmed by Thorpe and Walker (1973) who also observed lung metastases, which leaves no doubt as to the malignancy of these tumors. In a more recent long-term feeding study, Weisse and Herbst (1977) did not notice tumorigenic effects in Chbi NMRI (SPF) mice. In this latter experiment, besides the high spontaneous incidence of liver adenomas, the doses used were considerably lower than in previous studies, i.e., 1,2,5,25, and 50 ppm/80 weeks.…”

An Assessment of the Health Risks of Seven Pesticides Used for Termite Control

“…The investigators concluded that lindane was not carcinogenic under the conditions of the test. Groups of 50 mice of each sex were given lindane in the diet at 12.5, 25, or 50 ppm for 80 wk (Weisse and Herbst, 1977); there was no significant increase in tumors, compared with controls.…”

Lindane

“…Weisse and Herbst (1977) exposed SPF mice to 12.5,25, or 50 ppm in the diet for 80 wk and reported no fine structural hepatocellular alterations.…”

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…These results were confirmed by Thorpe and Walker (1973) who also observed lung metastases, which leaves no doubt as to the malignancy of these tumors. In a more recent long-term feeding study, Weisse and Herbst (1977) did not notice tumorigenic effects in Chbi NMRI (SPF) mice. In this latter experiment, besides the high spontaneous incidence of liver adenomas, the doses used were considerably lower than in previous studies, i.e., 1,2,5,25, and 50 ppm/80 weeks.…”

An Assessment of the Health Risks of Seven Pesticides Used for Termite Control

“…The investigators concluded that lindane was not carcinogenic under the conditions of the test. Groups of 50 mice of each sex were given lindane in the diet at 12.5, 25, or 50 ppm for 80 wk (Weisse and Herbst, 1977); there was no significant increase in tumors, compared with controls.…”

Lindane

“…Weisse and Herbst (1977) exposed SPF mice to 12.5,25, or 50 ppm in the diet for 80 wk and reported no fine structural hepatocellular alterations.…”

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…These results were confirmed by Thorpe and Walker (1973) who also observed lung metastases, which leaves no doubt as to the malignancy of these tumors. In a more recent long-term feeding study, Weisse and Herbst (1977) did not notice tumorigenic effects in Chbi NMRI (SPF) mice. In this latter experiment, besides the high spontaneous incidence of liver adenomas, the doses used were considerably lower than in previous studies, i.e., 1,2,5,25, and 50 ppm/80 weeks.…”

An Assessment of the Health Risks of Seven Pesticides Used for Termite Control

“…The investigators concluded that lindane was not carcinogenic under the conditions of the test. Groups of 50 mice of each sex were given lindane in the diet at 12.5, 25, or 50 ppm for 80 wk (Weisse and Herbst, 1977); there was no significant increase in tumors, compared with controls.…”

Lindane

“…Weisse and Herbst (1977) exposed SPF mice to 12.5,25, or 50 ppm in the diet for 80 wk and reported no fine structural hepatocellular alterations.…”