Carcinogenicity study of γ-oryzanol in B6C3F1 mice

Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein1

“…γ -Oryzanol was not carcinogenic to either B6C3F 1 mice or F344 rats following chronic oral administration (200, 600, or 2000 mg/kg body weight for at least 2 years). Greater incidences of neoplasms were noted in mice and rats of the highest dose groups, but were not statistically significant compared to corresponding controls (Tamagawa et al 1992a;1992b).…”

Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein1

“…γ -Oryzanol was not carcinogenic to either B6C3F 1 mice or F344 rats following chronic oral administration (200, 600, or 2000 mg/kg body weight for at least 2 years). Greater incidences of neoplasms were noted in mice and rats of the highest dose groups, but were not statistically significant compared to corresponding controls (Tamagawa et al 1992a;1992b).…”

Investigation of nutriactive phytochemical – gamma‐oryzanol in experimental animal models

“…Moreover, as mentioned above, biosafety studies performed by Tamagawa et al. (,b) showed that the tumour incidents were not significantly different between the treated and control groups after feeding high doses of GO to mice and rats for up to two years. The most significant difference between Hirose et al.…”

Organic Rice Bran Oils in Health

“…114 The findings indicate that, under the experimental conditions described, γ-oryzanol was not carcinogenic in F344 rats and B6C3F1 mice. The inhibitory effect of cycloartenol ferulate, a component of rice, on tumor promotion in two-stage carcinogenesis in mouse skin was studied.…”

Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein1

“…γ -Oryzanol was not carcinogenic to either B6C3F 1 mice or F344 rats following chronic oral administration (200, 600, or 2000 mg/kg body weight for at least 2 years). Greater incidences of neoplasms were noted in mice and rats of the highest dose groups, but were not statistically significant compared to corresponding controls (Tamagawa et al 1992a;1992b).…”

Investigation of nutriactive phytochemical – gamma‐oryzanol in experimental animal models

“…Moreover, as mentioned above, biosafety studies performed by Tamagawa et al. (,b) showed that the tumour incidents were not significantly different between the treated and control groups after feeding high doses of GO to mice and rats for up to two years. The most significant difference between Hirose et al.…”

Organic Rice Bran Oils in Health

“…114 The findings indicate that, under the experimental conditions described, γ-oryzanol was not carcinogenic in F344 rats and B6C3F1 mice. The inhibitory effect of cycloartenol ferulate, a component of rice, on tumor promotion in two-stage carcinogenesis in mouse skin was studied.…”

Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein1

“…γ -Oryzanol was not carcinogenic to either B6C3F 1 mice or F344 rats following chronic oral administration (200, 600, or 2000 mg/kg body weight for at least 2 years). Greater incidences of neoplasms were noted in mice and rats of the highest dose groups, but were not statistically significant compared to corresponding controls (Tamagawa et al 1992a;1992b).…”

Investigation of nutriactive phytochemical – gamma‐oryzanol in experimental animal models

“…Moreover, as mentioned above, biosafety studies performed by Tamagawa et al. (,b) showed that the tumour incidents were not significantly different between the treated and control groups after feeding high doses of GO to mice and rats for up to two years. The most significant difference between Hirose et al.…”

Organic Rice Bran Oils in Health

“…114 The findings indicate that, under the experimental conditions described, γ-oryzanol was not carcinogenic in F344 rats and B6C3F1 mice. The inhibitory effect of cycloartenol ferulate, a component of rice, on tumor promotion in two-stage carcinogenesis in mouse skin was studied.…”