Carcinogenicity of policosanol in mice: An 18-month study

Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

“…These data are in agreement with results of other safety and toxicity studies conducted in various animal models (14,31,32,(37)(38)(39)(40)(41)(42). Short-and long-term studies conducted in rats (43)(44)(45) or dogs (39) have not shown any policosanolrelated toxic symptoms or histopathological changes in the organs.…”

Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

“…These data are in agreement with results of other safety and toxicity studies conducted in various animal models (14,31,32,(37)(38)(39)(40)(41)(42). Short-and long-term studies conducted in rats (43)(44)(45) or dogs (39) have not shown any policosanolrelated toxic symptoms or histopathological changes in the organs.…”

Preliminary evaluation of the cytotoxic and genotoxic potential of D‐003: Mixture of very long chain fatty acids

“…The negative results are consistent not only with the structure of the drug but also with the negative results found during the toxicological studies of policosanol [13][14][15][16][17][18][19][20], a new drug with effective cholesterol-lowering effect that has been demonstrated experimentally [21][22] and in clinical studies [23][24].…”

Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters

“…In agreement with previous studies [16,[42][43][44],t h e present study did not show significant effects of VLCFA on body weight, food intake, or weight of heart, kidney, and brain. The combination of VLCFA with LT increased the liver weight.…”

Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

“…These data are in agreement with results of other safety and toxicity studies conducted in various animal models (14,31,32,(37)(38)(39)(40)(41)(42). Short-and long-term studies conducted in rats (43)(44)(45) or dogs (39) have not shown any policosanolrelated toxic symptoms or histopathological changes in the organs.…”

Preliminary evaluation of the cytotoxic and genotoxic potential of D‐003: Mixture of very long chain fatty acids

“…The negative results are consistent not only with the structure of the drug but also with the negative results found during the toxicological studies of policosanol [13][14][15][16][17][18][19][20], a new drug with effective cholesterol-lowering effect that has been demonstrated experimentally [21][22] and in clinical studies [23][24].…”

Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters

“…In agreement with previous studies [16,[42][43][44],t h e present study did not show significant effects of VLCFA on body weight, food intake, or weight of heart, kidney, and brain. The combination of VLCFA with LT increased the liver weight.…”

Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

“…These data are in agreement with results of other safety and toxicity studies conducted in various animal models (14,31,32,(37)(38)(39)(40)(41)(42). Short-and long-term studies conducted in rats (43)(44)(45) or dogs (39) have not shown any policosanolrelated toxic symptoms or histopathological changes in the organs.…”

Preliminary evaluation of the cytotoxic and genotoxic potential of D‐003: Mixture of very long chain fatty acids

“…The negative results are consistent not only with the structure of the drug but also with the negative results found during the toxicological studies of policosanol [13][14][15][16][17][18][19][20], a new drug with effective cholesterol-lowering effect that has been demonstrated experimentally [21][22] and in clinical studies [23][24].…”

Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters

“…In agreement with previous studies [16,[42][43][44],t h e present study did not show significant effects of VLCFA on body weight, food intake, or weight of heart, kidney, and brain. The combination of VLCFA with LT increased the liver weight.…”