Carcinogenic and co-carcinogenic studies of thiram on mouse skin

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

“…Such promoting effect might result from increased ornithine decarboxylase activity and DNA synthesis, as indicated by the increase in [3H] thymidine incorporation into the mouse skin DNA [ 66 ]. Interestingly, Thiram showed an initiating effect on the skin of Swiss albino mice instead when followed by 12-O-tetradecanoyl phorbol 13-acetate as a promoter [ 67 ]. Treatment with ETU and sodium nitrite caused endometrial adenocarcinomas in female mice following hyperplasia of endometrial glands as the precancerous lesion [ 68 ] also as a result of N-nitroso ETU formation [ 69 ].…”

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

“…Such promoting effect might result from increased ornithine decarboxylase activity and DNA synthesis, as indicated by the increase in [3H] thymidine incorporation into the mouse skin DNA [ 66 ]. Interestingly, Thiram showed an initiating effect on the skin of Swiss albino mice instead when followed by 12-O-tetradecanoyl phorbol 13-acetate as a promoter [ 67 ]. Treatment with ETU and sodium nitrite caused endometrial adenocarcinomas in female mice following hyperplasia of endometrial glands as the precancerous lesion [ 68 ] also as a result of N-nitroso ETU formation [ 69 ].…”

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

“…Such promoting effect might result from increased ornithine decarboxylase activity and DNA synthesis, as indicated by the increase in [3H] thymidine incorporation into the mouse skin DNA [ 66 ]. Interestingly, Thiram showed an initiating effect on the skin of Swiss albino mice instead when followed by 12-O-tetradecanoyl phorbol 13-acetate as a promoter [ 67 ]. Treatment with ETU and sodium nitrite caused endometrial adenocarcinomas in female mice following hyperplasia of endometrial glands as the precancerous lesion [ 68 ] also as a result of N-nitroso ETU formation [ 69 ].…”

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

“…Such promoting effect might result from increased ornithine decarboxylase activity and DNA synthesis, as indicated by the increase in [3H] thymidine incorporation into the mouse skin DNA [ 66 ]. Interestingly, Thiram showed an initiating effect on the skin of Swiss albino mice instead when followed by 12-O-tetradecanoyl phorbol 13-acetate as a promoter [ 67 ]. Treatment with ETU and sodium nitrite caused endometrial adenocarcinomas in female mice following hyperplasia of endometrial glands as the precancerous lesion [ 68 ] also as a result of N-nitroso ETU formation [ 69 ].…”