Carboxamidation of β-Dicarbonyl Compounds

Biosynthesis of the Tetracycline Antibiotics

“…The tetracycline antibiotics are excellent examples of such metabolites. An excellent review of the chemistry and general history of the tetracyclines up to about 19G2 has been published (15), and the synthesis of tetracycline analogs has been reviewed (1G). -4 number of reviews of the biosynthesis of the tetracyclines from various viewpoints has also appeared in recent years (11)(12)(13)(14).…”

Electronic properties of two adjacent intramolecular hydrogen bonds and their effects to the molecular charge distribution: Experimental synchrotron microcrystal and DFT computational study

“…Compound (I) was synthesized as described in the literature [5]. This compound is both a product of the reaction of potassium cyanate with dimedon and the substrate in reactions with 1,2-phenylenediamines [48].…”

“…The known compound (I) is almost a prototypical example for systems with a O-H…O and a N-H…O hydrogen bond. It was prepared following a synthesis known from literature [5]. A similar moiety of two adjacent strong intramolecular hydrogen bonds was examined by Bertolini [6].…”

Pd/C-Catalyzed Carbonylative Amidation for the Synthesis of 2-Carboxamidocyclohexane-1,3-diones

“…Considering the intriguing structural features as well as widespread applications of β-ketoamides, various protocols have been developed for their synthesis. , However, despite the substantial progress realized in this arena, the synthesis of challenging 2-carboxamidocyclohexane-1,3-diones has remained underexplored. Only a few traditional approaches have been reported for their synthesis, involving reaction of the corresponding cyclohexane-1,3-dione with different metal cyanates, isocyanic acid, isocyanates, and urea or the treatment of sodio derivatives of cyclohexanedione with phosgene followed by ammonia . Furthermore, a multistep synthesis of 2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-ene-1-carboxamide was also reported .…”