Carbosilane dendrimers NN8 and NN16 form a stable complex with siGAG1

Shcharbin, Dzmitry; Pedziwiatr, Elzbieta; Nowacka, Olga; Kumar, Mayank; Zaborski, Marian; Ortega, Paula; Mata, F. Javier de la; Gómez, Rafael; Ma, Mai‐Juan; Bryszewska, Maria

doi:10.1016/j.colsurfb.2010.11.009

Cited by 34 publications

(27 citation statements)

References 8 publications

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“…In a related work, Shcharbin et al (2011) reported the formation of a stable complex of 2G-NN8 and 2G-NN16 with siGAG1, an anti-HIV siRNA. 22 The characteristics of the complexes were studied using circular dichroism, and the particle size and zeta potential were also found to be similar to those in earlier reports by Weber et al (2008). 14 …”

Section: Nonviral Carriers For Exogenous Sirna Delivery For Hiv Therapysupporting

confidence: 76%

Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy

Adesina

Akala

2015

Mol. Pharmaceutics

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RNA interference (RNAi) is triggered by oligonucleotides that are about 21–23 nucleotides long and are capable of inducing the destruction of complementary mRNA. The RNAi technique has been successfully utilized to target HIV replication; however, the main limitation to the successful utilization of this technique in vivo is the inability of naked siRNA to cross the cell membrane by diffusion due to its strong anionic charge and large molecular weight. This review describes current nonviral nanotechnological approaches to deliver anti-HIV siRNAs for the treatment of HIV infection.

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Section: Nonviral Carriers For Exogenous Sirna Delivery For Hiv Therapysupporting

confidence: 76%

Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy

Adesina

Akala

2015

Mol. Pharmaceutics

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“…Different types of nanoparticles have been studied as potential carriers of oligonucleotides and siRNA [27][28][29][30][31][32][33]. Dendrimers seem to be as excellent non-viral carriers of nucleic acids [34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Ruthenium dendrimers as carriers for anticancer siRNA

Michlewska

Йонов

Maroto-Díaz

et al. 2018

Journal of Inorganic Biochemistry

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Dendrimers, which are considered as one of the most promising tools in the field of nanobiotechnology due to their structural organization, showed a great potential in gene therapy, drug delivery, medical imaging and as antimicrobial and antiviral agents. This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence. The zeta-potential and the size of dendriplexes were determined by dynamic light scattering. The internalization of dendriplexes were estimated using HL-60 cells. Results show that ruthenium dendrimers associated with anticancer siRNA have the ability to deliver siRNA as non-viral vectors into the cancer cells. Moreover, dendrimers can protect siRNA against nuclease degradation. Nevertheless, further research need to be performed to examine the therapeutic potential of ruthenium dendrimers as well as dendrimers complexed with siRNA and anticancer drugs towards cancer cells.

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“…These dendriplexes are stable, protect siRNAs from serum proteins, are internalised into cells, give good results in preliminary transfection tests, and most important have low cytotoxicity (Ionov et al, 2012;Bermejo et al, 2007;Chonco et al, 2007). CBD, CPD, and PAMAM dendrimers are promising candidates for the role of siRNA carriers (Ferenc et al, 2013;Posocco et al, 2013;Shcharbin et al, 2011). Manipulation of apoptosis can be used to force specific cells to die, one major approach in anticancer therapy (Reed, 2011).…”

Section: Introductionmentioning

confidence: 98%