“…In fact, it is well known that the antiglaucoma agents target CA II, CA IV and CA XII, [6] the antiobesity agents inhibit CA VA and CA VB, [7,8] the anticonvulsant agents act against CA II, CA VII and CA XIV, [9] and the antitumor drugs target CA IX and CA XII. [2,[10][11][12][13] In previous works, we rationally designed, synthesized and evaluated isoquinoline-sulfonamides as CAIs, testing their affinity towards different human CA isoforms (hCA I, hCA II, hCA IX, and hCA XIV). [14, 15a-b] As a result of these studies, we identified some isoquinolines (1-10; Tables 1 and 2) that showed nanomolar binding affinities (K i values); these compounds were also characterized by significant selectivity for hCA IX and hCA XIV over ubiquitous cytosolic hCA II of up to approximately three orders of magnitude (i.e., compound 8).…”