volume 342, issue 3, P487-494 1992
DOI: 10.1016/0022-0728(92)85141-o
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Francesco Botrè, Claudio Botrè, Franco Mazzei

Abstract: In the present work data are reported on the effect played by CO2 transport, operated by carbonic anhydrase (CA), on the decarboxylation of l-glutamic acid (GA), operated by glutamic acid decarboxylase (GAD), to give γ-aminobutyric acid (GABA). It is shown that in a physico-chemical model system in which the rate of GA decarboxylation is continuously monitored by a selective GA biosensor, such a reaction is sharply affected by CA in the presence of an excess of CO2. Further experimental results, obtained in th…

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