Carbon-Rich Wastes as Feedstocks for Biodegradable Polymer (Polyhydroxyalkanoate) Production Using Bacteria

Nikodinovic-Runic, Jasmina; Guzik, Maciej; Kenny, Shane T.; Babu, Ramesh; Werker, Alan; Connor, Kevin E. O’

doi:10.1016/b978-0-12-407673-0.00004-7

Cited by 165 publications

(79 citation statements)

References 179 publications

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“…Techno-economic studies have shown that a major cost of pure culture production is the carbon feedstock, estimated to be up to 40% of the product cost (1,12,13). Consequently many research groups are investigating the potential of using waste streams for PHA production, such as dairy whey waste, waste lipids, sugar industry waste streams, agricultural crop residues, petrochemical waste, syngas and glycerol (14).…”

Section: Introductionmentioning

confidence: 99%

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Levett

Birkett

Davies

et al. 2016

Journal of Environmental Chemical Engineering

121

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, Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane-The case for thermophilic bioprocessing, Journal of Environmental Chemical Engineering http://dx.doi.org/10.1016/j.jece. 2016.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractA major obstacle preventing the large scale production of polyhydroxyalkanoates (PHAs) has been the lack of a reliable, low cost, large volume feedstock. The abundance and relatively low price of methane therefore marks it as a substrate of interest. This paper presents a technoeconomic assessment of the production of poly-3-hydroxybutyrate (PHB) from methane.ASPEN Plus was used for process design and simulation. The design and economic evaluation is presented for production of 100,000 t/a PHB through methanotrophic fermentation and acetone-water solvent extraction. Production costs were estimated at $4.1-$6.8/kg PHA, which compares against a median price of $7.5/kg from other studies. Raw material costs are reduced from 30-50% of production for sugar feedstocks, to 22% of production for methane. A feature of the work is the revelation that heat removal from the two-stage bioreactor process contributes 28% of the operating cost. Thermophilic methanotrophs could allow the use of cooling water instead of refrigerant, reducing production costs to $3.2-5.4/kg PHA; it is noted that PHB producing thermophilic methanotrophs are yet to be isolated. Energy consumption for air compression and biomass drying were also identified as significant capital and operating costs and therefore optimisation of bioreactor height and pressure and biomass moisture content should be considered in future research.3

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Section: Introductionmentioning

confidence: 99%

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Levett

Birkett

Davies

et al. 2016

Journal of Environmental Chemical Engineering

121

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“…1b) (Chen 2009;Steinbüchel and Valentin 1995). PHAs can be made from renewable biological resources such as glucose, glycerol, and fatty acids (Follonier et al 2014;Nikodinovic-Runic et al 2013). PHAs have a number of uses ranging from compostable packaging materials or as materials for medical applications, such as drug delivery (Chen 2011;Chen and Wu 2005).…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds

Radivojević

Skaro

Šenerović

et al. 2015

Appl Microbiol Biotechnol

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A library of 18 different compounds was synthesized starting from (R)-3-hydroxyoctanoic acid which is derived from the bacterial polymer polyhydroxyalkanoate (PHA). Ten derivatives, including halo and unsaturated methyl and benzyl esters, were synthesized and characterized for the first time. Given that (R)-3-hydroxyalkanoic acids are known to have biological activity, the new compounds were evaluated for antimicrobial activity and in vitro antiproliferative effect with mammalian cell lines. The presence of the carboxylic group was essential for the antimicrobial activity, with minimal inhibitory concentrations against a panel of bacteria (Gram-positive and Gram-negative) and fungi (Candida albicans and Microsporum gypseum) in the range 2.8-7.0 mM and 0.1-6.3 mM, respectively. 3-Halogenated octanoic acids exhibited the ability to inhibit C. albicans hyphae formation. In addition, (R)-3-hydroxyoctanoic and (E)-oct-2-enoic acids inhibited quorum sensing-regulated pyocyanin production in the opportunistic pathogen Pseudomonas aeruginosa PAO1. Generally, derivatives did not inhibit mammalian cell proliferation even at 3-mM concentrations, while only (E)-oct-2-enoic and 3-oxooctanoic acid had IC50 values of 1.7 and 1.6 mM with the human lung fibroblast cell line.

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“…Therefore, bulk production of PHA requires feasible and economical fermentation processes from cheap carbon sources. One promising and widely investigated approach is the utilization of industrial waste products 13 . Besides complex industrial wastes, gasification processes enable the conversion of any carbonaceous material into synthesis gas (syngas) 13,14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…One promising and widely investigated approach is the utilization of industrial waste products 13 . Besides complex industrial wastes, gasification processes enable the conversion of any carbonaceous material into synthesis gas (syngas) 13,14,15 . Syngas mainly consists of The phototrophic non-sulfur purple bacterium Rhodospirillum rubrum is known for its metabolic versatility.…”

Section: Introductionmentioning

confidence: 99%

Heterologous Expression of Various PHA Synthase Genes in Rhodospirillum rubrum

Klask

Raberg

Heinrich

et al. 2015

Chem. Biochem. Eng. Q.

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Carbon-Rich Wastes as Feedstocks for Biodegradable Polymer (Polyhydroxyalkanoate) Production Using Bacteria

Cited by 165 publications

References 179 publications

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds

Heterologous Expression of Various PHA Synthase Genes in Rhodospirillum rubrum

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