Carbon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity

Song, Yukun; Wu, Yanyang; Wang, Haitao; Liu, Shan; Song, Lina; Shen, Li; Tan, Mingqian

doi:10.1016/j.foodchem.2019.05.017

Cited by 69 publications

(51 citation statements)

References 35 publications

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“…The acute toxicity of CDs extracted from beer, Coke, and Pepsi was examined in a mouse model at a dose as high as 2.0 g/kg body weight. 25,36 No deaths or significant clinical signs of toxicity were observed after oral administration of the beer, Coke, and Pepsi CDs. In addition, some physiological indexes, including glutamate pyruvate transaminase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea, and creatinine levels, showed slight but not significant variation after oral administration with CDs from Coke and Pepsi.…”

Section: Interaction Ofmentioning

confidence: 97%

“…33,49 The CDs formed in baked lamb were internalized by HepG2 cancer cells, 31 whereas salmon CDs were mostly distributed within the cell cytoplasm, but the CDs were observed in the nucleus at a higher concentration. 25 Figure 3 In Vitro Distribution of Endogenous CDs Derived from Food Items (A) Distribution of CDs from Nescafe in human hepatocellular carcinoma cells. Reprinted with permission from Jiang et al 21 (copyright, 2014, Elsevier).…”

Section: Biodistribution Of Food-borne Cdsmentioning

confidence: 99%

“…22 In 2016, Al-Hadi et al 23 added evidence for this hypothesis by demonstrating that the CDs in bread induced metabolic stress in human mesenchymal stem cells through CYP1A and p53 gene expression in vitro (Figure 1). This observation suggested that nanostructures formed during the heating process Figure 1 Timeline of Some Representative Events Regarding Endogenous Fluorescent Carbon Dots Derived from Food Items Reprinted with permission from Xu et al 19 (copyright, 2004, American Chemical Society), Sk et al 20 (copyright, 2012, Springer Nature), Jiang et al 21 (copyright, 2014, Elsevier), Liao et al 22 (copyright, 2015, American Chemical Society), Wang et al 24 (copyright, 2017, American Chemical Society), Song et al 25 (copyright, 2019, Elsevier), Li et al 26 (copyright, 2019, The Royal Society of Chemistry), and Li et al 27 (copyright, 2018, American Chemical Society).…”

Section: Introductionmentioning

confidence: 99%

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Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

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BACKGROUNDFluorescent carbon dots (CDs) are a novel class of carbon-based nanomaterials that were discovered in 2004. However, nobody knew that CDs existed in food items naturally until 2012. Properties of nanosize materials are distinct from those of their bulk materials due to the particle size and accordingly alter their bioavailability and/or biocompatibility. Therefore, the potential health risk of nanoparticles in food has drawn massive attention. Currently, almost all studies regarding the biosafety of nanoparticles in food have mainly focused on engineered nanoparticles used as food additives and have excluded the endogenous nanoparticles in food. Therefore, investigation of the properties of food-borne fluorescent CDs and their potential health risk to humans is of great significance.

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Section: Interaction Ofmentioning

confidence: 97%

Section: Biodistribution Of Food-borne Cdsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

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“…XPS spectra of CDs (Figure 7c) indicated that CDs contain carbon, nitrogen, and oxygen atoms with contents of 65.44%, 9.44%, and 25.11%, respectively. The C 1s spectra (Figure S8a in Supporting Materials) indicated the existence of C=C/C–C (284.36 eV), C–N (285.01 eV), C–Si (285.91 eV), and C=O/C–O (287.98 eV); N 1s spectra (Figure S8b in Supporting Materials) confirmed the presence of N–H (399.22 eV) and C–N (399.89 eV); and O 1s spectra (Figure S8c in Supporting Materials) displayed four functional groups, including O–H (531.26 eV), C=O/C–O (531.90 eV), and O–Si (532.59 eV) [42,43,44]. The XPS spectra demonstrated that APTES was successfully bonded to anhydrous citric acid.…”

Section: Resultsmentioning

confidence: 99%

Vinyl Phosphate-Functionalized, Magnetic, Molecularly-Imprinted Polymeric Microspheres’ Enrichment and Carbon Dots’ Fluorescence-Detection of Organophosphorus Pesticide Residues

Fan

et al. 2019

Polymers

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The rapid detection of organophosphorus pesticide residues in food is crucial to food safety. One type of novel, magnetic, molecularly-imprinted polymeric microsphere (MMIP) was prepared with vinyl phosphate and 1-octadecene as a collection of dual functional monomers, which were screened by Gaussian09W molecular simulation. MMIPs were used to enrich organic phosphorus, which then detected by fluorescence quenching in vinyl phosphate-modified carbon dots (CDs@VPA) originated from anhydrous citric acid. MMIPs and CDs@VPA were characterized by TEM, particle size analysis, FT-IR, VSM, XPS, adsorption experiments, and fluorescence spectrophotometry in turn. Through the fitting data from experiment and Gaussian quantum chemical calculations, the molecular recognition properties and the mechanism of fluorescence detection between organophosphorus pesticides and CDs@VPA were also investigated. The results indicated that the MMIPs could specifically recognize and enrich triazophos with the saturated adsorption capacity 0.226 mmol g−1, the imprinting factor 4.59, and the limit of recognition as low as 0.0006 mmol L−1. Under optimal conditions, the CDs@VPA sensor has shown an extensive fluorescence property with a LOD of 0.0015 mmol L−1 and the linear range from 0.0035 mmol L−1 to 0.20 mmol L−1 (R2 = 0.9988) at 390 nm. The mechanism of fluorescence detection of organic phosphorus with CDs@VPA sensor might be attributable to hydrogen bonds formed between heteroatom O, N, S, or P, and the O−H group, which led to fluorescent quenching. Meanwhile, HN−C=O and Si−O groups in CDs@VPA system might contribute to cause excellent blue photoluminescence. The fluorescence sensor was thorough successfully employed to the detection of triazophos in cucumber samples, illustrating its tremendous value towards food sample analysis in complex matrix.

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“…The biodistribution of QDs and the concentration of heavy metals released by QDs are the key parameters to evaluate their toxicity in vivo. 39 Several studies have reported the biodistribution of different types of Cdbased QDs in mice or rat models. Haque et al reported that the fluorescence of CdSe/CdS-MPA QDs was able to be observed in the liver, spleen, lung and kidneys after repeated intraperitoneal injection into BALB/c mice.…”

Section: Discussionmentioning

confidence: 99%

<p>In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications</p>

Chen

et al. 2020

IJN

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Introduction: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, the potential toxicity of InP QDs has not been systematically evaluated. In particular, the effects of different surface modifications on the biodistribution and toxicity of InP QDs are still unknown, which hinders their further developments. The present study aims to investigate the biodistribution and in vivo toxicity of InP/ZnS QDs. Methods: Three kinds of InP/ZnS QDs with different surface modifications, hQDs (QDs-OH), aQDs (QDs-NH 2), and cQDs (QDs-COOH) were intravenously injected into BALB/c mice at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively. Biodistribution of three QDs was determined through cryosection fluorescence microscopy and ICP-MS analysis. The subsequent effects of InP/ZnS QDs on histopathology, hematology and blood biochemistry were evaluated at 1, 3, 7, 14 and 28 days post-injection. Results: These types of InP/ZnS QDs were rapidly distributed in the major organs of mice, mainly in the liver and spleen, and lasted for 28 days. No abnormal behavior, weight change or organ index were observed during the whole observation period, except that 2 mice died on Day 1 after 25 mg/kg BW hQDs treatment. The results of H&E staining showed that no obvious histopathological abnormalities were observed in the main organs (including heart, liver, spleen, lung, kidney, and brain) of all mice injected with different surfacefunctionalized QDs. Low concentration exposure of three QDs hardly caused obvious toxicity, while high concentration exposure of the three QDs could cause some changes in hematological parameters or biochemical parameters related to liver function or cardiac function. More attention needs to be paid on cQDs as high-dose exposure of cQDs induced death, acute inflammatory reaction and slight changes in liver function in mice. Conclusion: The surface modification and exposure dose can influence the biological behavior and in vivo toxicity of QDs. The surface chemistry should be fully considered in the design of InP-based QDs for their biomedical applications.

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Carbon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity

Cited by 69 publications

References 35 publications

Endogenous Fluorescence Carbon Dots Derived from Food Items

Endogenous Fluorescence Carbon Dots Derived from Food Items

Vinyl Phosphate-Functionalized, Magnetic, Molecularly-Imprinted Polymeric Microspheres’ Enrichment and Carbon Dots’ Fluorescence-Detection of Organophosphorus Pesticide Residues

<p>In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications</p>

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