Carbon nanotube - A review on Synthesis, Properties and plethora of applications in the field of biomedical science

Anzar, Nigar; Hasan, Rahil; Tyagi, Manshi; Yadav, Neelam; Narang, Jagriti

doi:10.1016/j.sintl.2020.100003

Cited by 376 publications

(200 citation statements)

References 73 publications

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“…The unique physicochemical properties of multi-walled carbon nanotubes (MWNTs) lend themselves to a variety of industrial and biomedical applications (for recent reviews, see [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]). However, there are environmental health and safety (EH&S) concerns associated with MWNTs because of consistent reports that they can be toxic (for recent reviews, see [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ]).…”

Section: Introductionmentioning

confidence: 99%

The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products

et al. 2020

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The biological response of multi-walled carbon nanotubes (MWNTs) is related to their physicochemical properties and a thorough MWNT characterization should accompany an assessment of their biological activity, including their potential toxicity. Beyond characterizing the physicochemical properties of MWNTs from different sources or manufacturers, it is also important to characterize different production lots of the same MWNT product from the same vendor (i.e., lot-to-lot batch consistency). Herein, we present a comprehensive physicochemical characterization of two lots of commercial pristine MWNTs (pMWNTs) and carboxylated MWNTs (cMWNTs) used to study the response of mammalian macrophages to MWNTs. There were many similarities between the physicochemical properties of the two lots of cMWNTs and neither significantly diminished the 24-h proliferation of RAW 264.7 macrophages up to the highest concentration tested (200 μg cMWNTs/mL). Conversely, several physicochemical properties of the two lots of pMWNTs were different; notably, the newer lot of pMWNTs displayed less oxidative stability, a higher defect density, and a smaller amount of surface oxygen species relative to the original lot. Furthermore, a 72-h half maximal inhibitory concentration (IC-50) of ~90 µg pMWNTs/mL was determined for RAW 264.7 cells with the new lot of pMWNTs. These results demonstrate that subtle physicochemical differences can lead to significantly dissimilar cellular responses, and that production-lot consistency must be considered when assessing the toxicity of MWNTs.

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Section: Introductionmentioning

confidence: 99%

The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products

et al. 2020

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“…In fact, MWCNTs, thanks to their large surface area and hydrophobic nature prolonging their halflives, have been used for targeting and controlling the delivery of drugs by several stimuli (magnetic, electric, or temperature changes). 21…”

Section: Carbon Nanotubesmentioning

confidence: 99%

<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>

Binda¹,

Murano²,

Rivolta³

2020

IJN

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The field of nanomedicine is constantly expanding. Since the first work dated in 1999, almost 28 thousand articles have been published, and more and more are published every year: just think that only in the last five years 20,855 have come out (source PUBMED) including original research and reviews. The goal of this review is to present the current knowledge about nanomedicine in Alzheimer's disease, a widespread neurodegenerative disorder in the over 60 population that deeply affects memory and cognition. Thus, after a brief introduction on the pathology and on the state-of-the-art research for NPs passing the BBB, special attention is placed to new targets that can enter the interest of nanoparticle designers and to new promising therapies. The authors performed a literature review limited to the last three years (2017-2020) of available studies with the intention to present only novel formulations or approaches where at least in vitro studies have been performed. This choice was made because, while limiting the sector to nanotechnology applied to Alzheimer, an organic census of all the relevant news is difficult to obtain.

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“…The nanotubes often have closed ends but can also be open-ended. Carbon nanotubes exhibit higher tensile strength, flexibility, elasticity, and high thermal conductivity [22,23]. They are often utilized to reinforce composite materials with improved mechanical, electrical, and thermal properties.…”

Section: Chemistry Of Different Types Of Fullerenesmentioning

confidence: 99%

An Update Report on the Biosafety and Potential Toxicity of Fullerene-Based Nanomaterials toward Aquatic Animals

Malhotra¹,

Ger²,

Castillo³

et al. 2020

Preprint

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Fullerene molecules are composed of carbon in forms of a hollow sphere, ellipsoid, or tube. Fullerenes have attracted considerable attention in different fields of science since their discovery in 1985. The unique carbon cage structure of fullerene provides immense scope for derivatization, rendering potential for various industrial applications. The prospective applications of fullerenes thus have led to assorted fullerene derivatives. The unique chemical structure also provides ease for fullerene to be synthesized through various kinds of conjugating techniques, where fullerene can be located either on the backbone or the branch chain. Here in this review, we have compiled the toxicity and biosafety aspects of fullerene in aquatic organisms. The frequent use of fullerene is likely to come in contact and interact with the aquatic environment and aquatic organisms. According to the current understanding, waterborne exposure to fullerene-based nanomaterials indeed triggers toxicities at cellular, organic, molecular as well as neurobehavioral levels.

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Carbon nanotube - A review on Synthesis, Properties and plethora of applications in the field of biomedical science

Cited by 376 publications

References 73 publications

The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products

The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products

<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>

An Update Report on the Biosafety and Potential Toxicity of Fullerene-Based Nanomaterials toward Aquatic Animals

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