PLoS ONE volume 9, issue 6, Pe98448 2014 DOI: 10.1371/journal.pone.0098448 View full text Has correction 2015-08-07
Yang Liu, Yuanyuan Liu, Chao Sun, Lu Gan, Luwei Zhang, Aihong Mao, Yuting Du, Rong Zhou, Hong Zhang

Abstract: This study evaluated the effects of carbon ion and X-ray radiation and the tumor microenvironment on the migration of glioma and endothelial cells, a key process in tumorigenesis and angiogenesis during cancer progression. C6 glioma and human microvascular endothelial cells were treated with conditioned medium from cultures of glioma cells irradiated at a range of doses and the migration of both cell types, tube formation by endothelial cells, as well as the expression and secretion of migration-related protei…

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