Carbon dots-releasing hydrogels with antibacterial activity, high biocompatibility, and fluorescence performance as candidate materials for wound healing

Cui, Fangchao; Sun, Jiadi; Ji, Jian; Yang, Xingxing; Wei, Kaimin; Xu, Hongwen; Gu, Qingyin; Zhang, Yinzhi; Sun, Xiulan

doi:10.1016/j.jhazmat.2020.124330

Cited by 78 publications

(50 citation statements)

References 63 publications

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“…PHMG and NEO are recognized as excellent antimicrobial agents with broad-spectrum biocidal properties for various applications ( Pan et al, 2016 , Zhong et al, 2021 ). Here, a colony counting method was used to quantify the antibacterial activities of the AVAB-CNWs against two representing pathogenic bacteria, i.e., Gram-negative E. coli and Gram-positive S. aureus ( Cui et al, 2021 ). The photographs of bacterial colonies after 10 min and 60 min exposure to the samples are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Antiviral/antibacterial biodegradable cellulose nonwovens as environmentally friendly and bioprotective materials with potential to minimize microplastic pollution

Deng

Seidi

Yong

et al. 2022

Journal of Hazardous Materials

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Personal protective equipment (PPE) such as face masks is vital in battling the COVID-19 crisis, but the dominant polypropylene-based PPE are lack of antiviral/antibacterial activities and environmental friendliness, and have hazardous impact on the soil and aquatic ecosystems. The work presented herein focused on developing biodegradable, antiviral, and antibacterial cellulose nonwovens (AVAB-CNWs) as a multi-functional bioprotective layer for better protection against coronavirus SARS-CoV-2 and addressing environmental concerns raised by the piling of COVID-19 related wastes. Both guanidine-based polymer and neomycin sulfate (NEO) were reactive-modified and covalently grafted onto the surface of cellulose nonwovens, thereby conferring outstanding antiviral and antibacterial activities to the nonwovens without deteriorating the microstructure and biodegradability. Through adjusting the grafting amount of active components and selecting appropriate reagents for pretreatment, the antimicrobial activity and hydrophobicity for self-cleaning of the nonwovens can be tuned. More importantly, we demonstrated for the first time that such multi-functional nonwovens are capable of inactivating SARS-CoV-2 instantly, leading to high virucidal activity (>99.35%), which is unachievable by conventional masks used nowadays. Meanwhile, the robust breathability and biodegradability of AVAB-CNWs were well maintained. The applications of the as-prepared nonwovens as high-performance textile can be readily extended to other areas in the fight against COVID-19.

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Section: Resultsmentioning

confidence: 99%

Antiviral/antibacterial biodegradable cellulose nonwovens as environmentally friendly and bioprotective materials with potential to minimize microplastic pollution

Deng

Seidi

Yong

et al. 2022

Journal of Hazardous Materials

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“…Brushing cationic polyelectrolyte poly (dially ldimethyl ammonium chloride) onto bacterial cellulose via surface-initiated atom transfer radical polymerization could impart a sustained antimicrobial activity to the resultant hydrogels ( Yang Z. et al, 2021 ). Additionally, hydrogels loaded with cationic carbon dots also showed an antimicrobial function ( Cui et al, 2021 ). The prepared cationic carbon dots had an ultra-high positive charge and a small particle size, which could rapidly bind to bacteria and disrupt their surface charge, leading to the apoptosis of bacteria.…”

Section: Functionalization Of Hydrogels For Wound Healingmentioning

confidence: 99%

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

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“…A clean wound surface can reduce the bacterial infection. [ 4 ] In addition, a moist wound environment can accelerate the wound healing. [ 5 ] Traditional dressing materials such as gauze and cotton wool could rapidly absorb blood and tissue exudate.…”

Section: Introductionmentioning

confidence: 99%

Physiologically‐Regulated Adhesion of Hydrogels for Wound Dressing

Yan

et al. 2021

Adv Materials Inter

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Adhesion allows the close contact of wound dressing materials with skin surface. However, the dressing replacement inevitably causes the secondary damage to unhealed wound, so a wound dressing material having physiologically‐regulated adhesion is of high significance. Herein, a hydrogel is reported by covalently introducing cationic moieties into an elastic network. The cationic moieties are capable of electron‐withdrawing that promotes a strong electrostatic interaction with polar groups of protein (high electron cloud density) from the wound skin tissue, enabling the adhesion of hydrogel on the skin surface. With the tissue metabolism, the nucleophilic skin surface forms a lipid layer that gradually destroys the electrostatic interaction and weakens the interfacial affinity. The adhesion energy can be reduced from 60 to <10 J m−2 in 7 days, so that the dressing material can be removed easily. The cationic moieties also endow the hydrogel a high water swelling ratio (reaching 25 200%) and an efficient antibacterial property. The in vivo tests demonstrate that the wound on a mouse back reaches physiological 100% healing after the hydrogel dressing treatment for 12 days. All results show that the introduction of cationic moieties makes the hydrogel more promising as a wound dressing.

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Carbon dots-releasing hydrogels with antibacterial activity, high biocompatibility, and fluorescence performance as candidate materials for wound healing

Cited by 78 publications

References 63 publications

Antiviral/antibacterial biodegradable cellulose nonwovens as environmentally friendly and bioprotective materials with potential to minimize microplastic pollution

Antiviral/antibacterial biodegradable cellulose nonwovens as environmentally friendly and bioprotective materials with potential to minimize microplastic pollution

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Physiologically‐Regulated Adhesion of Hydrogels for Wound Dressing

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