Carbon dots assisted formation of DNA hydrogel for sustained release of drug

Singh, Seema; Mishra, Anshul; Kumari, Rina; Sinha, Kislay Kumar; Singh, Manoj K.; Das, Prolay

doi:10.1016/j.carbon.2016.12.020

Cited by 108 publications

(84 citation statements)

References 52 publications

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“…The incorporation of light‐sensitive synthetic groups, e.g., azobenzene moieties, into DNA hydrogels can be exploited for targeted delivery and controlled release of drugs or for tumor photothermal immunotherapy . Furthermore, DNA polymer composite materials have been produced from inorganic materials, such as carbon dots, graphene oxide, carbon nanotubes, semiconductor quantum dots, or AuNP [126a,127] and magnetic nanoparticles . The addition of nanoparticles adds functionality to the DNA hydrogels, whether be it mechanical stability, optical traceability, or remote controllability by external magnetic fields .…”

Section: Dna‐based Polymer Materialsmentioning

confidence: 99%

From DNA Nanotechnology to Material Systems Engineering

2019

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Section: Dna‐based Polymer Materialsmentioning

confidence: 99%

From DNA Nanotechnology to Material Systems Engineering

2019

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“…Here, CD acted as a crosslinker for network formation and also participated in encapsulating the drug by electrostatic interaction along with DNA. Release of the drug was observed under acidic conditions and was tracked using the fluorescent properties of the CDs [54].…”

Section: Carbon-dot and Quantum Dot-based Dna Hydrogelsmentioning

confidence: 99%

DNA hydrogel-empowered biosensing

Khajouei

Ravan

Ebrahimi

2020

Advances in Colloid and Interface Science

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DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy. Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing. Finally, we offer a vision into the future landscape of DNA based hydrogels in sensing applications.

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“…The design of stimuli‐responsive DNA‐based hydrogels have attracted substantial attentions, mainly due to the structural property of nucleic acids, which allows the formation of a variety of dynamic assemblies with the capability of changing their macroscopic features by altering their conformation or integrity in response to various stimuli, such as temperature, small molecules (salts, ions, enzymes), and pH . These triggers can change different properties of hydrogels, including volume, phase, optical characteristics, or surface functionalities, termed as “little trigger” for “big changes.” These hydrogels have been applied thus far for various purposes, including switchable catalysis, sensors, controlled drug release, separation of substrates, catalyzed synthesis of conducting wires, tissue engineering, and the triggered activation of enzyme cascades . One of the main advantages of these hydrogels is the capability of loading different biomolecules into their matrix before the gelling process, leading to high efficient cargo encapsulation within the gels.…”

Section: Responsive Dna Hydrogelsmentioning

confidence: 99%

“…Kan‐loaded PA‐GO hydrogels exerted antibacterial activity against both Gram‐negative and Gram‐positive bacteria. DNA‐carbon dot (CD) hybrid hydrogel are also constructed for sustained drug release . In the presence of DOX, phosphoramidate linkage could conjugate amine‐functionalized CDs to 5ʹ‐phosphate termini of Cytosine (C) rich ssDNA to produce drug‐loaded hydrogels (Figure B).…”

Section: Biomedical Applications Of Dna Hydrogelsmentioning

confidence: 99%

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Shahbazi

Bauleth‐Ramos

Santos

2018

Advanced Therapeutics

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DNA is a perfect polymeric molecule for interfacing biology with material science to construct hydrogels that represent fascinating properties for a wide variety of biomedical applications. Tunable multifunctionality, convenient programmability, adequate biocompatibility, biodegradability, capability of precise molecular recognition, and high versatility have made DNA an irreplaceable building block for the construction of novel 3D hydrogels. DNA can be used as the only component of a hydrogel, the backbone or a cross-linker that connects the main building blocks to form hybrid hydrogels through chemical reactions or physical entanglement. Responsive constructs of DNA with superior mechanical properties are very commonly reported nowadays, which can undergo macroscopic changes induced by various triggers, including alteration in ionic strength, temperature, and pH. These hydrogels can be prepared by various types of DNA building blocks, such as branched double-stranded DNA, single-stranded DNA, X-shaped DNA, or Y-shaped DNA through intermolecular i-motif structures, DNA hybridization, enzyme ligation, or enzyme polymerization. These hydrogels are envisioned for a variety of applications, such as drug delivery, sensing, tissue engineering, 3D cell culture, and providing template for nanoparticle synthesis.

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Carbon dots assisted formation of DNA hydrogel for sustained release of drug

Cited by 108 publications

References 52 publications

From DNA Nanotechnology to Material Systems Engineering

From DNA Nanotechnology to Material Systems Engineering

DNA hydrogel-empowered biosensing

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

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