Carbamazepine and cocaine-cue reactivity

Olanzapine reduces urge to drink after drinking cues and a priming dose of alcohol

“…Recently, investigators have used a cue exposure approach to test whether promising medications may alleviate cue-elicited appetitive responses (Robbins et al 1992;Hersh et al 1995;Berger et al 1996). With respect to alcohol cues, a recent doubleblind, placebo-controlled study demonstrated that patients receiving daily doses of 50 mg naltrexone were significantly less likely to demonstrate a cue-elicited urge to drink, as compared to patients treated with placebo (Monti et al 1999).…”

Genetic Moderators of Naltrexone's Effects on Alcohol Cue Reactivity

“…Research suggests that subjective urge, heart rate, and mean arterial pressure (MAP) are the most commonly used indices of cue reactivity (Niaura et al, 1988) but they can be independent of each other in alcoholic individuals . Reactivity to alcohol cues has been shown to predict treatment outcome (Cooney et al, 1997;Rohsenow and Monti, 1999) and is a useful paradigm for testing mechanisms of medications' effects on urge (Hersh et al, 1995;McCaul and Monti, 2003;Monti et al, 1999;Robbins et al, 1992;Rohsenow et al, 2000). Finally, urge for drugs of abuse has been proposed as a useful endophenotype for the study of pharmacogenetic mechanisms (Hutchison et al, 2003).…”

Naltrexone's Effect on Cue‐Elicited Craving Among Alcoholics in Treatment

“…Furthermore, reactivity to alcohol cues predicts treatment outcome (Cooney et al, 1977;Rohsenow et al, 1994). The cue reactivity paradigm has recently been successfully used to test the effects of other medications on craving for drugs (Hersh et al, 1995;Robbins et al, 1992). Thus, the cue reactivity paradigm is ideal for investigating the hypothesized mechanisms of action of clinical interventions, such as the putative effects on urge to drink.…”