“…(5,22,23) In actuality, fever is often considered the first sign of infection and other described signs include uterine tenderness, bleeding and fetid loci, which can denote progression to sepsis. (24) It is evident that Hippocrates's clinical case presents clear information on the diagnosis of puerperal sepsis (Table 1), when considering the pathophysiology, anamnesis and physical examination, performed in the classical era. However, with the evolution of health and medicine, protocols were created with more detailed information, such as the pathophysiology, which allows for the understanding that bacteria from the infectious origin reach the bloodstream and, posteriorly, multiple organs, which results in dysfunction of some organs, possibly causing the patient's death.…”