Características sociodemográficas, clínicas y farmacológicas de adultos mayores con fracturas, en tres centros de referencia, Colombia

Valladales‐Restrepo, Luis Fernando; Duran-Lengua, Marlene; Castro-Osorio, Edgar Eduardo; Correa-Sánchez, Yessenia; Machado‐Alba, Jorge Enrique

doi:10.21615/cesmedicina.34.1.2

Cited by 3 publications

(5 citation statements)

References 42 publications

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“…The most frequently prescribed pharmacological group was non-opioid analgesics, which is in line with the recommendations of clinical practice guidelines [ 4 , 6 , 9 ] previously reported in other works [ 5 , 18 , 22 ]. The most commonly used analgesic was acetaminophen, similar to what has been published in other studies [ 16 , 23 ], followed by NSAIDs.…”

Section: Discussionsupporting

confidence: 86%

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Valladales‐Restrepo

Rubio-Londoño

Poveda-Martinez

et al. 2022

Drugs - Real World Outcomes

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Background Analgesics provide multiple clinical benefits but they are not without risks. Objective The aim of this study was to compare the outpatient prescribing pattern of analgesics between cities and municipalities in Colombia and to identify the variables associated with prescribing opioid analgesics. Methods This was a cross-sectional study that identified the prescription of analgesics for outpatient use from a population database of 8.5 million Colombians. A descriptive, bivariate, and multivariate analysis was performed. Results A total of 573,248 patients were identified who had received prescriptions for an analgesic. Mean age was 46.5 ± 23.6 years and 65.7% were females. The most commonly prescribed analgesics were non-opioid analgesics, antispasmodics, and opioid analgesics. The average milligram equivalent of morphine was higher in capital cities than in municipalities. Age ≥ 65 years (odds ratio [OR] 2.60, 95% confidence interval [CI] 2.54-2.67), male sex (OR 1.09, 95% CI 1.07-1.11), dispensing in cities (OR 2.25, 95% CI 2.20-2.30) and experiencing chronic pain (OR 13.25, were associated with an increased risk of receiving an opioid analgesic. Conclusions Differences were found in the prescription of analgesics between capital cities and municipalities. The use of opioids does not appear to be in line with the recommendations for clinical practice, and they were mainly prescribed for elderly males with chronic non-oncological pain and for residents of capital cities.

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Section: Discussionsupporting

confidence: 86%

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Valladales‐Restrepo

Rubio-Londoño

Poveda-Martinez

et al. 2022

Drugs - Real World Outcomes

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“…The median age of the patients was similar to that found in other studies (75.3–79.0 years) [ 10 – 17 ], with a predominance of women, as identified by previous studies (71.0–91.1%) [ 10 – 15 , 17 – 26 ]. Similarly, the Charlson Comorbidities Index of these patients was high, as described in the literature [ 12 , 15 , 19 ].…”

Section: Discussionsupporting

confidence: 88%

“…[ 2 ]. However, only 16.7% of the patients were receiving an antiosteoporotic drug, showing poor coverage as previously described in the country (7.0%-12.1%) [ 10 , 11 , 17 , 27 ] and in the world (10.8%-21.3%) [ 15 , 18 – 22 , 24 ].…”

Section: Discussionmentioning

confidence: 81%

“…Most of the patients were managed surgically and with placement of osteosynthesis material, as evidenced in the literature [ 10 , 11 , 17 , 20 ]. A total of 58.7% of the patients were prescribed calcium/vitamin D supplementation at discharge, which is consistent with other reports (62.1%-63.1%) [ 10 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the prescription was higher in France (94.9%-96.6%) [ 15 , 19 ], the United States (94.9%) [ 28 ], Spain (74.0%-78.4%) [ 24 , 25 ] and Israel (73%) [ 16 ]. It is important to highlight that two studies in Columbia reported a notoriously lower use of calcium/vitamin D and antiosteoporotic drugs in care centers that did not have Fracture Liaison Services programs [ 17 , 26 ]. The use of bisphosphonates, teriparatide, and denosumab, among others, to varying degrees, has been related to reducing the risk of new vertebral and nonvertebral fractures [ 6 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Characterization and effectiveness of a Fracture Liaison Services program in Colombia

Valladales-Restrepo,

Castro-Osorio,

Ramírez-Osorio

et al. 2023

Arch Osteoporos

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Purpose Fracture Liaison Services programs reduce mortality and the risk of refracture and increase treatment and adherence rates. Greater coverage is an important priority for the future. The aim was to determine the characteristics of patients over 50 years old who suffered fractures and the effectiveness of a Fracture Liaison Services program in a health care institution in Colombia. Methods This was a retrospective follow-up study of a cohort of patients with vertebral and nonvertebral fractures managed in a Fracture Liaison Services program. Sociodemographic, clinical and pharmacological variables were identified. Key performance indicators were used to evaluate the effectiveness of the program. Descriptive and bivariate analysis was performed. Results A total of 438 patients were analyzed. The average age was 77.5 years, and 78.5% were women. Hip and vertebral fractures were the most common (25.3% and 24.9%, respectively). Vertebral fractures prevailed in men (33.0% vs 22.7%; p = 0.041) and those of the radius/ulna in women (20.3% vs 10.6%; p = 0.031). A total of 29.7% had experienced a previous fracture, and 16.7% had received antiosteoporosis drugs. A total of 63.5% of the cases were managed surgically. At discharge, 58.8% received prescriptions for calcium/vitamin D, and 50.7% with prescriptions of antiosteoporotic therapy, especially teriparatide (21.2%) and denosumab (16.4%), without significant differences by sex. However, in women with hip fractures, anti-osteoporotic management prevailed (83.7% vs 64.0; p = 0.032). The effectiveness of the overall program per year was 74.6%. On follow-up, only 9.1% of patients had experienced a new fall, and of those 3.7% presented a new fracture. A total of 4.3% died during follow-up. Conclusions Good adherence to the recommendations of the country's clinical practice guidelines was found, and overall, the effectiveness of the program was very satisfactory, with a low incidence of new fractures during follow-up. Summary Fracture Liaison Services programs reduce mortality and the risk of refracture. A retrospective follow-up study of a cohort of patients with vertebral and nonvertebral fractures managed in a Fracture Liaison Services, showed that the effectiveness was 73.6%. On follow-up, 9.1% of patients had experienced a new fall, and of those 3.7% presented a new fracture.

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Pharmacological management, and potentially inappropriate prescriptions in patients with osteoporosis

Valladales‐Restrepo

Vargas‐Díaz

Peña‐Verjan

et al. 2022

Expert Review of Endocrinology & Metabolism

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Características sociodemográficas, clínicas y farmacológicas de adultos mayores con fracturas, en tres centros de referencia, Colombia

Cited by 3 publications

References 42 publications

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Characterization and effectiveness of a Fracture Liaison Services program in Colombia

Pharmacological management, and potentially inappropriate prescriptions in patients with osteoporosis

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