volume 66, issue 8, P4982-4991 1992
DOI: 10.1128/jvi.66.8.4982-4991.1992
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Abstract: The expression of murine leukemia provirus in embryonal carcinoma (EC) cells is blocked by a mechanism still incompletely understood. The blockage is not overcome by deleting a large portion of the enhancer region (in U3) in recombinant retroviruses (M-MuLVneoAEnh). This confirms the presence of negative elements outside the viral 82-bp repeats. However, a few sites in the genomes of EC cells permit M-MuLVneoAEnh proviral expression. One such site, identified in PCC4, PCC3, and LT, was studied. The complete an…

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