Captopril protects against burn-induced cardiopulmonary injury in rats

Abstract

BACKGROUND:This study was designed to determine the possible protective effect of captopril treatment against oxidative damage in heart and lung tissues induced by burn injury.

Protectıve effect of betaıne agaınst burn ınduced pulmonary ınjury ın rats

“…[28] In the present study, lung tissue structure was damaged by burn due to oxidative stress. Other studies have also shown that GSH level in lung tissue significantly decreased with betaine treatment after burn, [22,28,33] as was the case in current study. Antioxidant therapy is now used in several pathological conditions with oxidant stress, and results have been positive.…”

“…[26,27] Another indicator for tissue injury is alteration of LDH level. [28] In their study, Wettstein and Häussinger showed that betaine decreased LDH level on perfused rat liver after ischemia and reperfusion through its cytoprotective effect. [29] In the present study, LDH level of rats with thermal injury was found to be high; however, in betaine-treated group it was significantly lower.…”

“…Antioxidant therapy is now used in several pathological conditions with oxidant stress, and results have been positive. [28] Kim and Kim showed that for hepatotoxicity caused by chloroform, betaine increased plasma and liver glutathione levels through its effect on transsulfuration pathway in liver. [34] In the present study, betaine applied after burn helped significantly reduce GSH level in lung tissue.…”