Captopril or Frusemide in Drug-Resistant Hypertension?

Kristensen, Bent Bruun; Skov, Jane; Atkinson, A. B.; Brown, J. J.; Lever, A.F.; Robertson, J. I. S.; White, Nicholas J.; Rajagopalan, B.; Yahaya, Haliru; Ledingeam, J.G.G.

doi:10.1016/s0140-6736(80)92743-9

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…1) is considered one of loop diuretic group and used in the treatment of hypertension, and oedema associated with heart failure and with renal and hepatic disorders (1)(2)(3) .…”

Section: Bumetanidementioning

confidence: 99%

Characterization of Eu(III) Complex for Determination of Bumetanide in Pharmaceutical Preparations and in Biological Fluids

2016

Egypt. J. Chem.

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“…1) is considered one of loop diuretic group and used in the treatment of hypertension, and oedema associated with heart failure and with renal and hepatic disorders (1)(2)(3) .…”

Section: Bumetanidementioning

confidence: 99%

Characterization of Eu(III) Complex for Determination of Bumetanide in Pharmaceutical Preparations and in Biological Fluids

2016

Egypt. J. Chem.

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“…2 In the clinical practice, the effects of furosemide are applied in the treatment of edema associated with pulmonary, cardiac, hepatic and renal disease, and of hypertension accompanied by fluid retention or impaired renal failure. [3][4][5][6][7] A marked diuresis is also associated to loss of weight, a side effect that has been incorrectly abused in the sport practice to achieve acute weight losses before competition, usually where weight categories are involved. Intense and fast diuresis may also mask the ingestion of other doping agents by reducing their concentration in urine.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Santini¹,

Pezza²,

Sequinel³

et al. 2009

J. Braz. Chem. Soc.

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A construção, avaliação e aplicação analítica de um sensor potenciométrico do tipo PtHgHg 2 (Fur) 2 Grafite, onde Fur significa íon 4-cloro-N-furfuril-5-sulfamoil-antranilato, são descritas. O eletrodo responde a Fur com sensibilidade de (−58,4 ± 0,9) mV década -1 no intervalo de 5,0 × 10 -7 -1,0 × 10 -2 mol L -1 , a pH 7,0-9,0 e com um limite de detecção de 3,8 × 10 -7 mol L -1 . O eletrodo é facilmente construído e de baixo custo, apresenta um rápido tempo de resposta (10-20 s) e pode ser usado por um período de 6 meses sem qualquer variação considerável nas suas características de desempenho. O eletrodo proposto mostrou boa seletividade na presença de várias substâncias, bem como na presença de alguns carboxilatos e ânions inorgânicos. O eletrodo foi aplicado com sucesso na determinação de furosemida em medicamentos, urina, soro sanguíneo e amostras comerciais de leite bovino.The construction, evaluation and analytical application of a potentiometric sensor, namely, PtHgHg 2 (Fur) 2 Graphite, where Fur stands for 4-chloro-N-furfuryl-5-sulphamoyl-anthranilate ion, are described. This electrode has a linear dynamic range between 5.0 × 10 -7 -1.0 × 10 -2 mol L -1 with a near-Nernstian slope of (-58.4± 0.9) mV decade -1 and a detection limit of 3.8 × 10 -7 mol L -1 . The potentiometric response is independent of the pH of the solution in the pH range 7.0-9.0. The electrode shows easy construction, low-cost, fast response time (within 10-20 s) and can be used for a period of 6 months without significant change in its performance characteristics. The proposed sensor displayed good selectivities over a variety of other anions (carboxylates and inorganic anions). Application of this potentiometric sensor for the furosemide determination in pharmaceuticals, urine, blood serum and commercial milk samples is reported.Keywords: 4-cloro-N-furfuryl-5-sulphamoylanthranilate-sensitive electrode, potentiometry, pharmaceuticals, urine, human blood serum, bovine milk IntroductionFurosemide or frusemide (HFur, 4-chloro-N-furfuryl-5-sulphamoyl-anthranilic acid) is formally a sulfonamide, an antibacterial agent (Figure 1). However, the intense and fast dieresis produced by this drug has extended its application as a powerful acidic diuretic for diverse treatments in humans and veterinary medicine. Furosemide is often classified as a loop diuretic due to its predominant action in the nephron, where the drug interferes with the tubular re-absorption of sodium on Henle's loop. 1 The renal excretion of ions is not limited to sodium and chloride, but it may also influence potassium, magnesium, calcium and, to a lesser extent, hydrogen carbonate ions. 2 In the clinical practice, the effects of furosemide are applied in the treatment of edema associated with pulmonary, cardiac, hepatic and renal disease, and of hypertension accompanied by fluid retention or impaired renal failure. 3-7 A marked diuresis is also associated to loss of weight, a side effect that has been incorrectly abused in the sport practice to achieve acute weight ...

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