Caprylic acid reduces Salmonella Enteritidis populations in various segments of digestive tract and internal organs of 3- and 6-week-old broiler chickens, therapeutically ,

Johny, Anup Kollanoor; Mattson, Tyler; Baskaran, Sangeetha Ananda; Amalaradjou, Mary Anne Roshni; Hoagland, T.A.; Darre, M. J.; Khan, Mazhar I.; Schreiber, David; Donoghue, Ann M.; Donoghue, Dan; Venkitanarayanan, Kumar

doi:10.3382/ps.2011-01716

Cited by 40 publications

(25 citation statements)

References 56 publications

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“…Several studies have evaluated the effect of MCFA on Salmonella colonization in poultry. Broilers fed diets containing caprylic acid (C8) at 0.7% (14 lbs/ton) and 1% (20 lbs/ton) had reduced Salmonella numbers in the gastrointestinal tract, liver, and spleen at 5–10 days PI (Kollanoor-Johny et al , 2009 , 2012 ). Similarly, layers supplemented with caproic acid (C6) at 3 g/kg of feed (6 lbs/ton) had lower Salmonella numbers in the ceca, liver, and spleen at 3 days PI (Van Immerseel et al , 2004a ).…”

Section: Discussionmentioning

confidence: 99%

“…These molecules are more bactericidal than short chain fatty acids (≤C4) which are routinely used to combat Salmonella (Kwon and Ricke, 1998 ; Nakai and Siebert, 2003 ; Van Immerseel et al , 2003 , 2006 ; Skrivanova et al , 2006 ). Interestingly, MCFA also suppress the expression of the invasion genes, hilA and hilD , in Salmonella and decrease intestinal epithelial cell invasion (Van Immerseel et al , 2004a ; Kollanoor-Johny et al , 2012 ). Studies in both layers and broilers show that MCFA can reduce Salmonella colonization in the gastrointestinal tract and in other tissues (Van Immerseel et al , 2004a ; Kollanoor-Johny et al , 2009 , 2012 ; Upadhyaya et al , 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, MCFA also suppress the expression of the invasion genes, hilA and hilD , in Salmonella and decrease intestinal epithelial cell invasion (Van Immerseel et al , 2004a ; Kollanoor-Johny et al , 2012 ). Studies in both layers and broilers show that MCFA can reduce Salmonella colonization in the gastrointestinal tract and in other tissues (Van Immerseel et al , 2004a ; Kollanoor-Johny et al , 2009 , 2012 ; Upadhyaya et al , 2015 ). Potentially, preharvest MCFA treatment could have an impact on product contamination by reducing Salmonella colonization during production.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Medium Chain Fatty Acid Feed Supplementation for ReducingSalmonellaTyphimurium Colonization in Turkey Poults

Evans

Collins

Pierson

et al. 2017

Foodborne Pathogens and Disease

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Studies indicate that persistent Salmonella colonization occurs in poultry that are infected early in life, leading to both food safety and public health concerns. Development of improved preharvest Salmonella management strategies is needed to reduce poultry product contamination. The objective of this study was to evaluate the efficacy of a product containing medium chain fatty acids (MCFA) for reducing early Salmonella colonization in turkey poults. Day-of-hatch turkeys were provided a standard starter diet supplemented with MCFA at 0 (negative and positive controls), 1.5, 3, 4.5, or 6 lbs/ton of feed. Positive control and MCFA treated birds were also crop-gavaged with 108 colony forming units (CFU) of bioluminescent Salmonella Typhimurium. Gastrointestinal tissue samples were collected at 3 days postinoculation for bioluminescence imaging (Meckel's diverticulum to the cloaca) and selective enumeration (cecal contents). Quantification of bioluminescence indicated that the 4.5 and 6 lbs/ton MCFA groups had significantly less colonization than the positive control group (p = 0.0412 and p < 0.0001, respectively). Similarly, significantly lower numbers (1-log10 CFU/g reduction) of Salmonella were observed in the ceca of the 6 lbs/ton MCFA group compared to the positive control group (p = 0.0153). These findings indicate that incorporation of MCFA in turkey diets can significantly reduce early Salmonella colonization. In addition, this study highlights the utility of bioluminescence imaging as a screening methodology for assessing the efficacy of treatments that may reduce Salmonella in poultry.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Medium Chain Fatty Acid Feed Supplementation for ReducingSalmonellaTyphimurium Colonization in Turkey Poults

Evans

Collins

Pierson

et al. 2017

Foodborne Pathogens and Disease

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“…NaO (0.75, 1, 2, and 3.5 mM) decreased S. aureus internalization into bMEC in a concentration-dependent manner, reaching maximal inhibition of 80% (Figure 2). Recently, Kollanoor-Johny et al [26] showed that supplementation of feed with caprylic acid reduces ~80% Salmonella Enteritidis invasion in chickens. Also, they established that the reduction in the pathogen ability to invade intestinal epithelial cells was related to a downregulation of the invasion genes hilA and hilD of Salmonella .…”

Section: Discussionmentioning

confidence: 99%

Effects of Sodium Octanoate on Innate Immune Response of Mammary Epithelial Cells duringStaphylococcus aureusInternalization

Alva-Murillo

Ochoa‐Zarzosa

López‐Meza

2013

BioMed Research International

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Bovine mammary epithelial cells (bMECs) are capable of initiating an innate immune response to invading bacteria. Short chain fatty acids can reduce Staphylococcus aureus internalization into bMEC, but it has not been evaluated if octanoic acid (sodium octanoate, NaO), a medium chain fatty acid (MCFA), has similar effects. In this study we determined the effect of NaO on S. aureus internalization into bMEC and on the modulation of innate immune elements. NaO (0.25–2 mM) did not affect S. aureus growth and bMEC viability, but it differentially modulated bacterial internalization into bMEC, which was induced at 0.25–0.5 mM (~60%) but inhibited at 1-2 mM (~40%). Also, bMEC showed a basal expression of all the innate immune genes evaluated, which were induced by S. aureus. NaO induced BNBD4, LAP, and BNBD10 mRNA expression, but BNBD5 and TNF-α were inhibited. Additionally, the pretreatment of bMEC with NaO inhibited the mRNA expression induction generated by bacteria which coincides with the increase in internalization; only TAP and BNDB10 showed an increase in their expression; it coincides with the greatest effect on the reduction of bacterial internalization. In conclusion, NaO exerts a dual effect on S. aureus internalization in bMEC and modulates elements of innate immune response.

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“…89-86 [Everything Added to Food in the United States]) (24,29) are approved for use in foods by the U.S. Food and Dmg Administration. Previous research conducted in our laboratory revealed that CA and BR were effective in inactivating a variety of pathogenic bacteria in different matrices (3,(28)(29)(30)(31)34).…”

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confidence: 99%

Inactivation of Escherichia coli O157:H7 on Cattle Hides by Caprylic Acid and β-Resorcylic Acid

Baskaran

Bhattaram

Upadhyaya

et al. 2013

Journal of Food Protection

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Two naturally occurring, generally recognized as safe compounds, namely, caprylic acid (CA) (1%) and b -resorcylic acid (BR) (1%), and their combination, applied at 23 and 60°C were evaluated for their antimicrobial effects against Escherichia coli O157:H7 on cattle hides in the presence and absence of bovine feces. Fresh cleaned cattle hides were cut into pieces (5 cm(2)), air dried, and inoculated with a five-strain mixture of nalidixic acid-resistant (50 μg/ml) E. coli O157:H7 (∼8.0 log CFU). The hide samples were air dried under a biosafety hood for 2 h and sprayed with 95% ethanol, 1% CA, 1% BR, or a mixture of 1% CA and 1% BR at 23 or 60°C. The hide samples were kept at 23°C, and E. coli O157:H7 populations were determined at 2 and 5 min after treatment. Both CA and BR were effective in decreasing E. coli O157:H7 populations on hides by 3 to 4 log CFU/cm(2) (P < 0.05). Sterile bovine feces had no effect on the decontaminating property of CA and BR on cattle hides (P > 0.05). Results of this study indicate that CA and BR could potentially be used to decontaminate cattle hides, but follow-up research under slaughterhouse conditions is warranted.

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Caprylic acid reduces Salmonella Enteritidis populations in various segments of digestive tract and internal organs of 3- and 6-week-old broiler chickens, therapeutically ,

Cited by 40 publications

References 56 publications

Investigation of Medium Chain Fatty Acid Feed Supplementation for ReducingSalmonellaTyphimurium Colonization in Turkey Poults

Investigation of Medium Chain Fatty Acid Feed Supplementation for ReducingSalmonellaTyphimurium Colonization in Turkey Poults

Effects of Sodium Octanoate on Innate Immune Response of Mammary Epithelial Cells duringStaphylococcus aureusInternalization

Inactivation of Escherichia coli O157:H7 on Cattle Hides by Caprylic Acid and β-Resorcylic Acid

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