Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
26
0

Year Published

2011
2011
2022
2022

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 23 publications
(27 citation statements)
references
References 17 publications
1
26
0
Order By: Relevance
“…In the current study we used a non-transgenic rat AD model known as the FAB rat or the Samaritan Alzheimer's Rat from Taconic, which has shown to develop plaques, tangles, and even neuronal loss – found in post mortem human AD brain (Lecanu et al, 2006; Lecanu et al, 2010). The FAB rat requires a much shorter time (just 4 weeks) to disease onset stage compared to some transgenic AD models.…”
Section: Introductionmentioning
confidence: 99%
“…In the current study we used a non-transgenic rat AD model known as the FAB rat or the Samaritan Alzheimer's Rat from Taconic, which has shown to develop plaques, tangles, and even neuronal loss – found in post mortem human AD brain (Lecanu et al, 2006; Lecanu et al, 2010). The FAB rat requires a much shorter time (just 4 weeks) to disease onset stage compared to some transgenic AD models.…”
Section: Introductionmentioning
confidence: 99%
“…The co-treatment of neuroblastoma cells with A ␤ 1-42 and caprospinol prevents the mitochondrial targeting of A ␤ 1-42 [3] . More recent in vivo studies have shown that caprospinol eliminates the amyloid deposits present in the hippocampus and prevents plaque formation [8] . The current study confirms the neuroprotective effect of caprospinol and demonstrates that, when neuroblastoma cells are pretreated with A ␤ 1-42 , the compound not only prevents the *** *** *** targeting of A ␤ 1-42 , but also clears the peptide from mitochondria.…”
Section: Discussionmentioning
confidence: 99%
“…The finding that in vitro only 100 M of caprospinol exerted a significant effect is not worrisome for future preclinical and clinical studies. Indeed, we recently demonstrated in vivo studies that caprospinol crosses easily the blood-brain barrier and accumulates into the rat brain at high concentrations [8] . Nevertheless, further experiments are needed to clarify the mechanism by which A ␤ 1-42 is removed from the mitochondria.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Before our study, several therapeutic effects of diosgenin had been reported, including against cancer, 36) food allergy, 37) D-galactose-induced cognitive deficit 38) and diabetic neuropathy. 39) A diosgenin derivative, caprospinol, improves memory dysfunction in Aβ1-42-infused AD model rats via reduction of amyloid deposits. 40) Dr. Chihiro Tohda 5XFAD mice were used in our study.…”
Section: Diosgenin Its Activities and Signaling Pathwaymentioning
confidence: 99%