Capillary Fragility and Vitamin'P'Protective Action Against Radiation

Sokoloff, Boris; Redd, James B.; Dutcher, R. Adams

doi:10.3181/00379727-75-18081

Cited by 7 publications

(3 citation statements)

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“…Flavanones are biologically active and there has been considerable interest in their antioxidant and other properties that may contribute to suppress inflammation and hence modulate events involved in the initiation and progression of cancer and cardiovascular dysfunction. Early work focused on the ability of citrus flavanones to affect capillary function ( 1 – 3 ) . More recently, it has been demonstrated that flavanones can modulate cell-signalling pathways that have been implicated in cancer, atherosclerosis and other inflammatory diseases ( 4 – 8 ) .…”

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Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion

et al. 2008

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Oranges are rich sources of flavonoids that are bioactive and may protect against age-related diseases. The absorption of orange flavanones may be affected by factors such as processing and subject anthropometric variables, and the bioactivity of the absorbed phytochemicals depends on how they are metabolised during absorption. In a randomised cross-over study, twenty subjects consumed a single portion of orange fruit (150 g) or juice (300 g) that contained the flavanones narirutin and hesperidin, and an additional 109 subjects across a broad age range (18–80 years) consumed the juice. Flavanone metabolites were measured in regularly collected samples of plasma and urine. After consumption of fruit or juice, flavanone conjugates, but not the aglycones, were detected in plasma and urine. The flavanone conjugates were shown to include the 7- and 4′-O-monoglucuronides of naringenin, the 7- and 3′-O-monoglucuronides of hesperetin, two hesperetin diglucuronides and a hesperetin sulfo-glucuronide, but no aglycones or rutinosides. Analysis of the plasma pharmacokinetic and urinary excretion data on a dose-adjusted basis indicated no difference in absorption or excretion of either flavanone between the fruit and juice matrices. In the extended urinary excretion dataset the individual variation was very large (range 0–59 % urinary yield). There was a small but significant (P<0·05) decrease in the excretion of hesperetin (but not naringenin) with increasing age (P<0·05), but the effects of sex, BMI and contraceptive pill use were shown not to be associated with the variation in flavanone excretion.

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Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion

et al. 2008

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“…Also, in the 1950s citrus polyphenols, at that time called 'vitamin P', were shown to affect capillary fragility in rabbit ears [73]. Nevertheless, the research on polyphenols improving microvascular function in different vascular beds and linking that to a (cardiovascular) benefit is still in his infancy, reflected by the fact that 50% of the eligible studies were published in the last decade (Tables 1-9).…”

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Polyphenols and Microvascular Function in Humans: A Systematic Review

Woodward

Draijer

Thijssen

et al. 2018

CPD

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“…Considerable work was done with the determination of capillary permeability by using chloroform wheals applied to the skin and simultaneous injections of trypan blue. This test pertaining rather to permeability changes than to increased capillary fragility has demonstrated a great variation in the response of experimental animals to the same flavonoid compound (11,12). More recently it was suggested that radiation injury to the capillary wall might serve as a basis for the estimation of vitamin "P" activity.…”

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