Capillary electrophoresis–inductively coupled plasma-mass spectrometry: an attractive complementary technique for elemental speciation analysis

Capillary electrophoresis hyphenated to inductively coupled plasma‐mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

“…Recently the focus has shifted towards mass spectrometric detection such as ESI-MS [25,26] and inductively coupled plasma (ICP)-MS [27][28][29][30], opening new possibilities for the characterization of metallodrug interactions with biological targets [7,31]. Especially ICP-MS, the unrivalled detector in terms of specificity and LOD of metals bound to biomolecules, seems best-suited for quantification of adducts, especially if only present in traces [32,33].…”

Capillary electrophoretic determination of selenocyanate and selenium and tellurium oxyanions in bacterial cultures

“…Various instrumental techniques including capillary electrophoresis (CE), high performance liquid chromatography -inductively coupled plasma -mass spectrometry (HPLC-ICP-MS), and ion chromatography -inductively coupled plasma -mass spectrometry (IC-ICP-MS) have been used by others for the speciation of selenium/tellurium-containing compounds (Casiot et al, 2002;Vogt and Werner, 1994;Schlegel et al, 1996;Albert et al, 1995;Gilon and Potin-Gautier, 1996;Kannamkumarath et al, 2002;Kahakachchi et al, 2004;Caruso and B'Hymer, 2006).…”

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

“…This makes it in particular interesting for the separation of the smallest sample amounts of labile complexes, such as metalloproteins, 9,60 whose integrity is often affected when using other separation techniques, such as LC. 61 Despite these interesting features the application of CE-ICP-MS as well as related instrumental developments indicates a certain stagnation, so the reader is referred to some good reviews focusing on the hyphenation of CE to ICP-MS. 60,62,63 This stagnation may be caused in particular by the complexity of such CE-ICP-MS systems, since different parameters have to be considered, such as the utilized buffer and make-up solutions, which ideally should be totally decomposed in the plasma without leaving too much residue on the cones and the lens system. In addition, buffer concentrations should be kept as low as possible to avoid any detrimental crystallization effects at the nebulizer tip.…”

“…108,[180][181][182] Based on this development, Prange and Schaumlöffel et al pioneered the field of sulfur isotopedilution analysis by combining postcolumn non-species-specific isotope dilution and capillary electrophoresis hyphenated to sector field ICP-MS for the highly resolved separation of different metallothionein (MT) isoforms, which allowed determination of the metal stoichiometry of the different isoforms as well as their absolute quantification. 183,184 A non-species-specific element spike containing 34 S, 65 Cu, 68 Zn, and 116 Cd introduced via the make-up flow of the CE interface was used for on-line isotope ratio measurement of 32 S/ 34 S, 63 Cu/ 65 Cu, 64 Zn/ 68 Zn, and 114 Cd/ 116 Cd. Reversed isotope dilution, using a standard solution containing S, Cu, Zn, and Cd with natural isotopic abundances, has been used for mass flow calibration of the different elements.…”