Canonical Transient Receptor Potential Channel Expression, Regulation, and Function in Vascular and Airway Diseases

Singh, Brij B.; Pabelick, Christina M.; Prakash, Y. S.

doi:10.1007/978-1-62703-077-9_4

Cited by 1 publication

(1 citation statement)

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“…Few generalizations can be made about TRP channels. Some show a highly restricted tissue expression pattern (TRPA1 and TRPV1 are predominantly expressed in sensory neurons; Patapoutian et al ., ) whereas others (TRPCs) are rather ubiquitously expressed (Singh et al ., ). Because members of the TRP family of channels (Figure ) share much less homology with one another compared with other ion channel families (Wu et al ., ), the identification of highly subtype‐selective compounds is likely to be more attainable.…”

Section: Introductionmentioning

confidence: 97%

Transient receptor potential (TRP) channels: a clinical perspective

Kaneko

Szállaśi

2014

British J Pharmacology

327

259

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Transient receptor potential (TRP) channels are important mediators of sensory signals with marked effects on cellular functions and signalling pathways. Indeed, mutations in genes encoding TRP channels are the cause of several inherited diseases in humans (the so-called 'TRP channelopathies') that affect the cardiovascular, renal, skeletal and nervous systems. TRP channels are also promising targets for drug discovery. The initial focus of research was on TRP channels that are expressed on nociceptive neurons. Indeed, a number of potent, small-molecule TRPV1, TRPV3 and TRPA1 antagonists have already entered clinical trials as novel analgesic agents. There has been a recent upsurge in the amount of work that expands TRP channel drug discovery efforts into new disease areas such as asthma, cancer, anxiety, cardiac hypertrophy, as well as obesity and metabolic disorders. A better understanding of TRP channel functions in health and disease should lead to the discovery of first-in-class drugs for these intractable diseases. With this review, we hope to capture the current state of this rapidly expanding and changing field. LINKED ARTICLESThis article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx

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Section: Introductionmentioning

confidence: 97%