Cannabis Use Is an Independent Predictor for Acute Myocardial Infarction Related Hospitalization in Younger Population

Patel, Rikinkumar S; Manocha, Pankaj; Patel, Jenil; Patel, Riddhi; Tankersley, William E.

doi:10.1016/j.jadohealth.2019.07.024

Cited by 27 publications

(14 citation statements)

References 34 publications

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“…Mood and anxiety disorders, suicidal behaviors, and psychotic disorders were significantly associated with pediatric POD inpatients having CUD [22]. Youth with CUD at an earlier age have a greater risk of long-lasting cognitive impairment and several psychiatric and medical conditions [23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Pankaj

Oraka²,

Caraballo-Rivera

et al. 2020

Cureus

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Our first goal is to evaluate the prevalence of hospital admissions for prescription opioid overdose (POD) in pediatric inpatients, and next goal is to measure the independent association between cannabis use disorders (CUD) and POD. Methods We used the nationwide inpatient sample (NIS) and included 27,444,239 pediatric inpatients (age ≤ 18 years), and 10,562 (0.04%) were managed primarily for POD. The odds ratio (OR) of the association of variables in POD inpatients was measured using the binomial logistic regression model that was adjusted for demographic confounders and psychiatric comorbidities. Results Adolescents have higher odds (OR 10.75, 95% CI 10.16-11.36) of POD-related hospitalization compared to children ≤ 12 years. Whites formed the significant proportion (67%), and those from low-income families (<50th percentile) had higher likelihood for POD-related hospitalization. The most prevalent psychiatric comorbidities were mood disorders (44.3%) and anxiety disorders (14.6%). Prevalent comorbid substance use disorders (SUDs) included cannabis (14.2%), tobacco (13.1%), and opioid (9.4%). A higher odds of association with POD-related hospitalizations were seen in pediatric inpatients with comorbid opioid (

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Section: Discussionmentioning

confidence: 99%

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Pankaj

Oraka²,

Caraballo-Rivera

et al. 2020

Cureus

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“…A 2017 systematic review of case reports and few observational studies (mainly crosssectional and including recreational cannabis users) found a possible CV risk with the use of cannabis (7). More recent studies also suggest an increased cannabis-related CV risk (18,19). In fact, evidence suggests that the endocannabinoid system has a signi cant role in the regulation of cardiovascular system (20,21).…”

Section: Discussionmentioning

confidence: 99%

Medical Cannabis Authorization and the Risk of Cardiovascular Events: A Longitudinal Cohort Study

Zongo

Lee

Dyck

et al. 2021

Preprint

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Background Despite the rising rates of legalization of cannabis worldwide, very few investigators have studied the effects of medical cannabis use on healthcare utilization and subsequent cardiovascular (CV) risk. This study assesses the risk of CV-related emergency department (ED) visit/hospitalization in adult patients authorized to use medical cannabis in Ontario, Canada from 2014–2017. Methods This is a longitudinal cohort study of patients who received medical cannabis authorization and followed-up in cannabis clinics, matched to population-based controls. The primary outcome was an ED visit/hospitalization for any CV event; and secondary outcome was for acute coronary syndrome (ACS)/stroke. Conditional Cox proportional hazards regression was used to assess the association between cannabis use and risk. Results 18,653 cannabis patients were matched to 5,1243 controls. Incidence rates for any CV event were 28.34/1000 person-years and 19/1000 person-years in the cannabis and controls group, respectively- (aHR) of 1.52 (95%CI: 1.31–1.77). The aHR among patients with a history of CV event and those without were 1.50 (1.28–1.75) and 1.26 (1.03–1.55), respectively. The aHR among males and females were 1.52 (1.24–1.87) and 1.41 (1.11–1.80). For the ACS and stroke, the aHR was 1.44 (95%CI: 1.08–1.93). When stratified by sex, only men had an increased risk of ACS and stroke; aHR 1.77 (1.23–2.56). Conclusions Medical cannabis authorization was associated with an increased risk of ED visits or hospitalization for CV events including stroke and ACS - among males and for patients with a prior CV condition.

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“…Few limitations in our study include the underreporting of AUD, due to inconsistency in administrative data based on ICD-9 codes, including diagnostic codes during patient billing. There were few recent studies that found cannabis is an independent cardiovascular risk factor for arrhythmias and myocardial infarction, but we were not able to study the trend of comorbid substance use including cannabis abuse or dependence [ 26 - 29 ]. Some of the major strengths our study includes nationwide data analysis covering 44 states across the United States; moreover, our results have appropriate external validity to the American population and a strong methodology including that statistical models to evaluate the national trends of arrhythmia inpatients with AUD.…”

Section: Discussionmentioning

confidence: 99%

National Trends of Arrhythmia Hospitalizations and Comorbid Alcohol Use Disorders in the United States

Ravat

Ajibawo

Parvataneni

et al. 2020

Cureus

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Objective To study the trends of arrhythmia hospitalizations with comorbid alcohol use disorders (AUDs) in terms of demographic characteristics and inpatient outcomes. Methods We used the Nationwide Inpatient Sample (NIS) data from 2010 to 2014 and included 570,556 arrhythmia inpatients (age, 15-54 years), and 55,730 inpatients had comorbid AUD. We used the linear-by-linear association test for measuring the differences in demographics, comorbidities, and hospital outcomes over the study period of 2010 to 2014, and the analysis of variance (ANOVA) for measuring the changes seen in the length of stay (LOS) and total charges. Results Arrhythmia inpatients with AUD were majorly males (85.9%), and older-age adults (45 to 54 years, 68%). Hypertension (52.2%), tobacco abuse (42.3%), and elevated cholesterol and lipids (22.6%) were the most prevalent comorbidities in the study population. There was a statistically significant increasing trend in arrhythmia inpatients with AUD with comorbid diabetes, hypertension, and obesity over the five-year period. In-hospital mortality had a variable trend from 1.1% in 2010 to 1.3% in 2014, but there was a statistically non-significant difference in the trend (P = 0.418). Mean LOS was three days with statistically no significant change during the study period (P = 0.080), whereas total charges have been increasing significantly (P <0.001), averaging $37,473 per hospitalization. Conclusion The prevalence trend of arrhythmia hospitalizations with comorbid AUD is increasing in the United States population, and is majorly seen in older-age men. Overall, in-hospital mortality in arrhythmia inpatients with comorbid AUD was 1.4%. So, this necessitates the development of an integrated clinical care model for early diagnosis and management of alcohol abuse and dependence in order to improve the arrhythmia patient outcomes and quality of life.

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Cannabis Use Is an Independent Predictor for Acute Myocardial Infarction Related Hospitalization in Younger Population

Cited by 27 publications

References 34 publications

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Medical Cannabis Authorization and the Risk of Cardiovascular Events: A Longitudinal Cohort Study

National Trends of Arrhythmia Hospitalizations and Comorbid Alcohol Use Disorders in the United States

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