Cannabinoid derivatives and the pharmacological management of pain

Lessa, Marcos Adriano; Cavalcanti, Ismar Lima; Figueiredo, Nubia Verçosa

doi:10.5935/1806-0013.20160012

Cited by 11 publications

(65 citation statements)

References 60 publications

(65 reference statements)

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“…Phytocannabinoids are natural compounds of plant origin. Endocannabinoid is the term used to cannabinoids from natural sources and nonplant origin which are produced in the body by physiological stimuli (PAMPLONA, 2014;LESSA et al, 2016;BLAKE et al, 2017).…”

Section: What Are Cannabinoids and What Are The Sites Of Action Of Thmentioning

confidence: 99%

“…Anandamide (N-aracuidonoyl etanolamine) and 2-aracuidonoyl glycerol both belong to the group of endocanabinnoids that are synthesized by neurons in the brain (MASSI et al, 2012;BRUCKI et al, 2015;LESSA et al, 2016) and are released by excitatory synaptic stimuli (BRUCKI et al, 2015). Endocannabinoid system encompasses endocannabinoids and their respective receptors (MASSI et al, 2012;PERTWEE, 2012;LESSA et al, 2016).…”

Section: What Are Cannabinoids and What Are The Sites Of Action Of Thmentioning

confidence: 99%

“…Both the cannabinoids and the endocannabinoid system interact with the endogenous opioid system. This synergism helps to amplify the effects of each of these two components reducing drug concentration decreasing side effects without affecting the efficacy of medications (LESSA et al, 2016;BLAKE et al, 2017). JOHNSON et al (2013) conducted a clinical trial to evaluate the analgesic effects of Δ9-THC/cannabidiol containing formulations in patients with opioid-refractory cancer pain.…”

Section: Synthetic Cannabinoids In the Treatment Of Cancer Painmentioning

confidence: 99%

“…Current studies demonstrated a synergistic analgesic effect between cannabinoids and opioids suggesting that these two drugs act through different pathways and receptors (ABRAMS, 2016;BLAKE et al, 2017). In a study involving 359 cancer patients subjected to opioid-sparing analgesic therapy, it was observed that analgesic supplementation with nabiximol for 5 weeks resulted in reduced pain and improved sleep quality (PORTENOY et al, 2012) due to lessening in the severity of symptoms and not as a result of the hypnotic action of the drug (LESSA et al, 2016).…”

Section: Synthetic Cannabinoids In the Treatment Of Cancer Painmentioning

confidence: 99%

“…Its medicinal properties have been reported for centuries but only recently it started being prescribed for pain after the discovery of endogenous cannabinoid receptors (BONFÁ et al, 2008;LESSA et al, 2016). Cannabis-based pain medication is currently available in the international market for the use in human patients (PAMPLONA, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Perspectives in veterinary medicine on the use of cannabinoids as complementary palliative therapy for pain in cancer patients

Repetti¹,

Girio²,

Friolani³

et al. 2019

Cienc. Rural

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Pain in the cancer patient is an important clinical manifestation that results in low life expectancy and poor prognosis. Pain may be related to tumor type, invasion of adjacent tissues, metastasis, and diagnostic and therapeutic procedures with variable response to analgesic therapy. Many studies have called attention due to their potential therapeutic effect in the modulation of pain and inflammation. Cannabinoid derivatives are chemical compounds obtained from Cannabis that act on specific receptors.Several commercial products have already been approved in Europe and the USA for use in human patients. The present study aimed to review articles on the use of cannabinoids in the control of pain contributing to the well-being and quality of life in cancer patients undergoing palliative care. Although, there are few reports in the veterinary medical literature on the use of cannabinoids in the control of pain in dogs, it is believed that such patients can benefit from this therapeutic modality.

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Section: What Are Cannabinoids and What Are The Sites Of Action Of Thmentioning

confidence: 99%